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MedKoo Cat#: 574697 | Name: Florasulam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Florasulam is a triazolopyrimidine sulfonamide compound that is used as a post emergence herbicide often used to control dandelion populations in wheat fields.

Chemical Structure

Florasulam
Florasulam
CAS#145701-23-1

Theoretical Analysis

MedKoo Cat#: 574697

Name: Florasulam

CAS#: 145701-23-1

Chemical Formula: C12H8F3N5O3S

Exact Mass: 359.0300

Molecular Weight: 359.28

Elemental Analysis: C, 40.12; H, 2.24; F, 15.86; N, 19.49; O, 13.36; S, 8.92

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Florasulam; Kantor; Primus; Primus SC
IUPAC/Chemical Name
N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamid
InChi Key
QZXATCCPQKOEIH-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H8F3N5O3S/c1-23-12-16-5-8(15)10-17-11(18-20(10)12)24(21,22)19-9-6(13)3-2-4-7(9)14/h2-5,19H,1H3
SMILES Code
O=S(C1=NN2C(OC)=NC=C(F)C2=N1)(NC3=C(F)C=CC=C3F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 359.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qiao Y, Chen G, Ma C, Tao B, Ma H, Zhang X, Liu F. Identification of photoproducts of florasulam in water using UPLC-QTOF-MS. Environ Sci Pollut Res Int. 2019 Mar;26(7):7132-7142. doi: 10.1007/s11356-019-04169-3. Epub 2019 Jan 16. PMID: 30649695. 2: Wang H, Sun P, Guo W, Dong X, Liu W, Wang J. Florasulam resistance status of flixweed (Descurainia sophia L.) and alternative herbicides for its chemical control in the North China plain. Pestic Biochem Physiol. 2021 Feb;172:104748. doi: 10.1016/j.pestbp.2020.104748. Epub 2020 Nov 14. PMID: 33518041. 3: Wang X, Zhang J, Liu Y, Lu C, Hou K, Huang Y, Juhasz A, Zhu L, Du Z, Li B. Effect of florasulam on oxidative damage and apoptosis in larvae and adult zebrafish (Danio rerio). J Hazard Mater. 2023 Mar 15;446:130682. doi: 10.1016/j.jhazmat.2022.130682. Epub 2022 Dec 26. PMID: 36580788. 4: Jiao Q, Mu Y, Deng J, Yao X, Zhao X, Liu X, Li X, Jiang X, Zhang F. Direct toxicity of the herbicide florasulam against Chlorella vulgaris: An integrated physiological and metabolomic analysis. Ecotoxicol Environ Saf. 2022 Nov;246:114135. doi: 10.1016/j.ecoenv.2022.114135. Epub 2022 Oct 3. PMID: 36201917. 5: Krieger MS, Pillar F, Ostrander JA. Effect of temperature and moisture on the degradation and sorption of florasulam and 5-hydroxyflorasulam in soil. J Agric Food Chem. 2000 Oct;48(10):4757-66. doi: 10.1021/jf000009k. PMID: 11052731. 6: Su W, Xu H, Hao H, Wu R, Wang H, Lu C. Effect of Environmental Conditions on the Degradation of Florasulam in Typical Soils of Northern China. J Environ Qual. 2017 May;46(3):553-558. doi: 10.2134/jeq2016.11.0449. PMID: 28724091. 7: Dong B, Qian W, Hu J. Dissipation kinetics and residues of florasulam and tribenuron-methyl in wheat ecosystem. Chemosphere. 2015 Feb;120:486-91. doi: 10.1016/j.chemosphere.2014.09.016. Epub 2014 Sep 29. PMID: 25268470. 8: Krieger MS, Yoder RN, Gibson R. Photolytic degradation of florasulam on soil and in water. J Agric Food Chem. 2000 Aug;48(8):3710-7. doi: 10.1021/jf991290+. PMID: 10956175. 9: Li Z, Guan W, Hong H, Ye Y, Ma Y. Determination and study on residue and dissipation of florasulam in wheat and soil under field conditions. Bull Environ Contam Toxicol. 2013 Mar;90(3):280-4. doi: 10.1007/s00128-012-0916-0. Epub 2012 Dec 13. PMID: 23238823. 10: Bi Y, Han L, Song S, Yao W, Qin F, Xu Y, Wu Q. Method validation, storage stability and field trial for residues of florasulam and pyroxsulam in cereal by liquid chromatography with tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 May;37(5):793-803. doi: 10.1080/19440049.2020.1723809. Epub 2020 Feb 20. PMID: 32077806. 11: Lepiece D, Salembier JF, Thompson A. Primus (florasulam 50 G/L), a new triazolopyrimidine sulfonanilide herbicide to control broad-leaved weeds in maize when applied in early postemergence (1 to 6 leaf stage of maize). Preliminary results. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66(2b):681-704. PMID: 12425093. 12: Paterson EA, Shenton ZL, Straszewski AE. Establishment of the baseline sensitivity and monitoring response of Papaver rhoeas populations to florasulam. Pest Manag Sci. 2002 Sep;58(9):964-6. doi: 10.1002/ps.562. PMID: 12233189. 13: Pang N, Cui Y, Hu J. Weather dependent dynamics of the herbicides florasulam, carfentrazone-ethyl, fluroxypyr-meptyl and fluroxypyr in wheat fields through field studies and computational simulation. Chemosphere. 2016 Dec;165:320-328. doi: 10.1016/j.chemosphere.2016.09.026. Epub 2016 Sep 30. PMID: 27664521. 14: Bhat AP, Pomerantz WCK, Arnold WA. Finding Fluorine: Photoproduct Formation during the Photolysis of Fluorinated Pesticides. Environ Sci Technol. 2022 Sep 6;56(17):12336-12346. doi: 10.1021/acs.est.2c04242. Epub 2022 Aug 16. PMID: 35972505; PMCID: PMC9454825. 15: deBoer GJ, Thornburgh S, Ehr RJ. Uptake, translocation and metabolism of the herbicide florasulam in wheat and broadleaf weeds. Pest Manag Sci. 2006 Apr;62(4):316-24. doi: 10.1002/ps.1163. PMID: 16506146. 16: Bondareva L, Fedorova N. Pesticides: Behavior in Agricultural Soil and Plants. Molecules. 2021 Sep 3;26(17):5370. doi: 10.3390/molecules26175370. PMID: 34500803; PMCID: PMC8434383. 17: Ran D, Wu X, Zheng J, Yang J, Zhou H, Zhang M, Tang Y. Study on the interaction between florasulam and bovine serum albumin. J Fluoresc. 2007 Nov;17(6):721-6. doi: 10.1007/s10895-007-0226-9. Epub 2007 Aug 17. PMID: 17703351. 18: Zhong M, Wang T, Hu J. Dissipation kinetics and residues of triazolopyrimidine herbicides flumetsulam and florasulam in corn ecosystem. Environ Monit Assess. 2015 Jun;187(6):390. doi: 10.1007/s10661-015-4593-4. Epub 2015 May 31. PMID: 26026845. 19: Rijckaert G, Lepiece D. Selectivity of florasulam in 4 grass species during the seed harvest year. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66(2b):747-52. PMID: 12425099. 20: Yu H, Guo X, Peng L, Li X, Chen J, Cui H. Target gene mutations endowed cross-resistance to acetolactate synthase-inhibiting herbicides in wild Brassica juncea. Pestic Biochem Physiol. 2023 Dec;197:105683. doi: 10.1016/j.pestbp.2023.105683. Epub 2023 Nov 4. PMID: 38072540.