Tyromycin A | CAS#141364-77-4

MedKoo Cat#: 462782 | Name: Tyromycin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tyromycin A is an inhibitor of leucine and cysteine aminopeptidases.

Chemical Structure

Tyromycin A

CAS#141364-77-4

Theoretical Analysis

MedKoo Cat#: 462782

Name: Tyromycin A

CAS#: 141364-77-4

Chemical Formula: C26H38O6

Exact Mass: 446.2668

Molecular Weight: 446.58

Elemental Analysis: C, 69.93; H, 8.58; O, 21.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tyromycin A;

IUPAC/Chemical Name

4,4'-(hexadecane-1,16-diyl)bis(3-methylfuran-2,5-dione)

InChi Key

ZOXQKIRYCLFUCD-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H38O6/c1-19-21(25(29)31-23(19)27)17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-22-20(2)24(28)32-26(22)30/h3-18H2,1-2H3

SMILES Code

CC1=C(C(OC1=O)=O)CCCCCCCCCCCCCCCCC2=C(C(OC2=O)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chepkirui C, Cheng T, Sum WC, Matasyoh JC, Decock C, Praditya DF, Wittstein K, Steinmann E, Stadler M. Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp. J Agric Food Chem. 2019 Aug 7;67(31):8468-8475. doi: 10.1021/acs.jafc.9b02598. Epub 2019 Jul 29. PMID: 31310114. 2: Mangaleswaran S, Argade NP. A facile synthesis of naturally occurring aminopeptidase inhibitor tyromycin A. J Org Chem. 2001 Jul 27;66(15):5259-61. doi: 10.1021/jo010260e. PMID: 11463284. 3: Weber W, Semar M, Anke T, Bross M, Steglich W. Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus. Planta Med. 1992 Feb;58(1):56-9. doi: 10.1055/s-2006-961390. PMID: 1620745. 4: Cheng T, Chepkirui C, Decock C, Matasyoh JC, Stadler M. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. PMID: 31807212; PMCID: PMC6880814.