Tmc 016 | CAS#85382-79-2

MedKoo Cat#: 462722 | Name: Tmc 016

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tmc 016 is a hybrid 16-membered macrolide antibiotic.

Chemical Structure

Tmc 016

CAS#85382-79-2

Theoretical Analysis

MedKoo Cat#: 462722

Name: Tmc 016

CAS#: 85382-79-2

Chemical Formula: C38H65NO12

Exact Mass: 727.4507

Molecular Weight: 727.93

Elemental Analysis: C, 62.70; H, 9.00; N, 1.92; O, 26.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

19-Deformyl-4'-deoxydesmycosin;

IUPAC/Chemical Name

(11E,13Z)-6-((4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-(((5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,7,9,13-tetramethyloxacyclohexadeca-11,13-diene-2,10-dione

InChi Key

MMHPQRIORHAXGA-MCDHDYCYSA-N

InChi Code

InChI=1S/C38H65NO12/c1-12-30-26(19-47-38-36(46-11)35(45-10)32(43)25(7)49-38)15-20(2)13-14-28(40)21(3)16-22(4)34(24(6)29(41)18-31(42)50-30)51-37-33(44)27(39(8)9)17-23(5)48-37/h13-15,21-27,29-30,32-38,41,43-44H,12,16-19H2,1-11H3/b14-13+,20-15-

SMILES Code

CCC1OC(CC(C(C(C(CC(C(/C=C/C(C)=C\C1COC2OC(C(C(C2OC)OC)O)C)=O)C)C)OC3OC(CC(N(C)C)C3O)C)C)O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 727.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fujiwara T, Takenaka S. Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016). FEMS Microbiol Lett. 1990 May;57(1-2):101-3. doi: 10.1016/0378-1097(90)90421-l. PMID: 2379808. 2: Fujiwara T, Watanabe H, Kogami Y, Shiritani Y, Sakakibara H. 19-Deformyl-4'-deoxydesmycosin (TMC-016): synthesis and biological properties of a unique 16-membered macrolide antibiotic. J Antibiot (Tokyo). 1989 Jun;42(6):903-12. doi: 10.7164/antibiotics.42.903. PMID: 2500413. 3: Sakai A, Mitsumori A, Furukawa M, Kinoshita K, Anzai Y, Kato F. Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041. J Ind Microbiol Biotechnol. 2012 Nov;39(11):1693-701. doi: 10.1007/s10295-012-1173-2. Epub 2012 Jul 29. PMID: 22842988. 4: Fujiwara T, Sakai A, Sakakibara H. Absorption, tissue distribution and excretion of 19-deformyldesmycosin derivatives, new 16-membered macrolides, in mice. J Antibiot (Tokyo). 1990 Mar;43(3):327-30. doi: 10.7164/antibiotics.43.327. PMID: 2324015.