Polysorbate 60 | CAS#9005-67-8

MedKoo Cat#: 462697 | Name: Polysorbate 60

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polysorbate 60 is an emulsifier used in some pharmaceuticals and food preparation. It is often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from ethoxylated sorbitan esterified with fatty acids.

Chemical Structure

Polysorbate 60

CAS#9005-67-8

Theoretical Analysis

MedKoo Cat#: 462697

Name: Polysorbate 60

CAS#: 9005-67-8

Chemical Formula: C32H62O10

Exact Mass: 606.4343

Molecular Weight: 606.84

Elemental Analysis: C, 63.34; H, 10.30; O, 26.36

Price and Availability

Size	Price	Availability	Quantity
1kg	USD 400.00	2 Weeks
10kg	USD 725.00	2 Weeks

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Related CAS #

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Synonym

Tween 60; Polysorbate 60;

IUPAC/Chemical Name

2-((R)-2-((2R,3S,4R)-3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl stearate

InChi Key

DEKFZWMENCCOFU-LIKAHPKFSA-N

InChi Code

InChI=1S/C32H62O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-26-28(38-21-18-33)32-31(41-23-20-35)29(27-42-32)39-22-19-34/h28-29,31-35H,2-27H2,1H3/t28-,29-,31+,32-/m1/s1

SMILES Code

CCCCCCCCCCCCCCCCCC(OCCOC[C@H]([C@H]1OC[C@H]([C@@H]1OCCO)OCCO)OCCO)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Polysorbate 60 is an emulsifier used in some pharmaceuticals and food preparation.

In vitro activity:

This study investigated the optimal parameters for the emulsification of Taiwanese green propolis (TGP) using different polysorbates (polysorbate-20, polysorbate-60, and polysorbate-80) and evaluated the effects on the immunomodulatory response in broilers. The results showed that 4 mg/mL of TGP in combination with 2% polysorbate-60 at 60 °C for 60 min significantly decreased the undissolved particle size of ethanol extract of TGP during the emulsification. The bioactive compounds of TGP, the propolins (C, D, F, G, and H), were also detected after emulsification. Supplementation of emulsified TGP (eTGP) in the drinking water of broilers before and after vaccination significantly enhanced the antibody titer response to infectious bronchitis virus at 28 days of age. In the lipopolysaccharide-challenged model, supplementation of eTGP in the drinking water of broilers decreased pro-inflammatory gene expression and increased anti-inflammatory gene expression. These results together suggested that the polysorbate-60 could effectively emulsify the ethanol extract of TGP. Reference: Animals (Basel). 2022 Feb 12;12(4):446. https://pubmed.ncbi.nlm.nih.gov/35203153/

In vivo activity:

Nanoparticles (NPs) were encapsulated with a solution containing polysorbate 60 and the amphiphiles. Prepared 1,4,7-triazacyclononane-1,4,7-triacetic acid-IO-Mannose (NOTA-IO-Man) showed a narrow size distribution, and no significant aggregation or degradation under harsh conditions. The relaxivity coefficient of (68)Ga-NOTA-IO-Man was higher than that of ferumoxide. The accumulation of (68)Ga-NOTA-IO-Man in the lymph node after injection into rat's footpad was confirmed by both positron emission tomography and MRI. Reference: Nanomedicine (Lond). 2015 Jul;10(12):1899-910. https://pubmed.ncbi.nlm.nih.gov/26139125/

Preparing Stock Solutions

The following data is based on the product molecular weight 606.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hsiao FS, Artdita CA, Hua KF, Tsai CJ, Chien YH, Chen YW, Cheng YH, Yu YH. Optimization of Emulsification Conditions on Ethanol Extract of Taiwanese Green Propolis Using Polysorbate and Its Immunomodulatory Effects in Broilers. Animals (Basel). 2022 Feb 12;12(4):446. doi: 10.3390/ani12040446. PMID: 35203153; PMCID: PMC8868552. 2. Flegler A, Iswara J, Mänz AT, Schocke FS, Faßbender WA, Hölzl G, Lipski A. Exogenous fatty acids affect membrane properties and cold adaptation of Listeria monocytogenes. Sci Rep. 2022 Jan 27;12(1):1499. doi: 10.1038/s41598-022-05548-6. PMID: 35087150; PMCID: PMC8795206. 3. Yang BY, Moon SH, Seelam SR, Jeon MJ, Lee YS, Lee DS, Chung JK, Kim YI, Jeong JM. Development of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles for lymph node imaging. Nanomedicine (Lond). 2015 Jul;10(12):1899-910. doi: 10.2217/nnm.15.41. PMID: 26139125. 4. Lee YK, Jeong JM, Hoigebazar L, Yang BY, Lee YS, Lee BC, Youn H, Lee DS, Chung JK, Lee MC. Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging. J Nucl Med. 2012 Sep;53(9):1462-70. doi: 10.2967/jnumed.111.092759. Epub 2012 Aug 2. PMID: 22859859.

In vitro protocol:

In vivo protocol:

1. Yang BY, Moon SH, Seelam SR, Jeon MJ, Lee YS, Lee DS, Chung JK, Kim YI, Jeong JM. Development of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles for lymph node imaging. Nanomedicine (Lond). 2015 Jul;10(12):1899-910. doi: 10.2217/nnm.15.41. PMID: 26139125. 2. Lee YK, Jeong JM, Hoigebazar L, Yang BY, Lee YS, Lee BC, Youn H, Lee DS, Chung JK, Lee MC. Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging. J Nucl Med. 2012 Sep;53(9):1462-70. doi: 10.2967/jnumed.111.092759. Epub 2012 Aug 2. PMID: 22859859.

1: Kattar A, Quelle-Regaldie A, Sánchez L, Concheiro A, Alvarez-Lorenzo C. Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery. Pharmaceutics. 2023 Apr 14;15(4):1247. doi: 10.3390/pharmaceutics15041247. PMID: 37111732; PMCID: PMC10142600. 2: Sano T, Okada A, Kawasaki K, Kume T, Fukui M, Todo H, Sugibayashi K. Self- Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability-a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal Delivery of a Hydrophilic Model Drug. AAPS PharmSciTech. 2022 Nov 11;23(8):296. doi: 10.1208/s12249-022-02452-0. PMID: 36369392. 3: Hsiao FS, Artdita CA, Hua KF, Tsai CJ, Chien YH, Chen YW, Cheng YH, Yu YH. Optimization of Emulsification Conditions on Ethanol Extract of Taiwanese Green Propolis Using Polysorbate and Its Immunomodulatory Effects in Broilers. Animals (Basel). 2022 Feb 12;12(4):446. doi: 10.3390/ani12040446. PMID: 35203153; PMCID: PMC8868552. 4: Flegler A, Iswara J, Mänz AT, Schocke FS, Faßbender WA, Hölzl G, Lipski A. Exogenous fatty acids affect membrane properties and cold adaptation of Listeria monocytogenes. Sci Rep. 2022 Jan 27;12(1):1499. doi: 10.1038/s41598-022-05548-6. PMID: 35087150; PMCID: PMC8795206. 5: Vu Dang H, Tran Huu H, Nguyen HMT. Investigating the influence of excipient batch variation on the structure, consistency and physical stability of polysorbate 60-based topical vehicles. Int J Cosmet Sci. 2021 Dec;43(6):715-728. doi: 10.1111/ics.12747. Epub 2021 Nov 12. PMID: 34714546. 6: Fritz V, Martirosian P, Machann J, Daniels R, Schick F. A comparison of emulsifiers for the formation of oil-in-water emulsions: stability of the emulsions within 9 h after production and MR signal properties. MAGMA. 2022 Jun;35(3):401-410. doi: 10.1007/s10334-021-00970-9. Epub 2021 Oct 26. PMID: 34698962; PMCID: PMC9188495. 7: Benkert C, Freyburger A, Huber V, Touraud D, Kunz W. Development of a fully water-dilutable mint concentrate based on a food-approved microemulsion. Food Chem. 2022 Mar 15;372:131230. doi: 10.1016/j.foodchem.2021.131230. Epub 2021 Sep 27. PMID: 34627088. 8: Carballo-Pedrares N, Kattar A, Concheiro A, Alvarez-Lorenzo C, Rey-Rico A. Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2021 Sep;128:112307. doi: 10.1016/j.msec.2021.112307. Epub 2021 Jul 11. PMID: 34474858. 9: Ruan Y, Li X, You L, Chen J, Shen Y, Zhang J, Yuan Y, Kang L, Qin C, Wu C. Effect of Pharmaceutical Excipients on Intestinal Absorption of Metformin via Organic Cation-Selective Transporters. Mol Pharm. 2021 Jun 7;18(6):2198-2207. doi: 10.1021/acs.molpharmaceut.0c01104. Epub 2021 May 6. PMID: 33956455. 10: Caritá AC, Resende de Azevedo J, Vinícius Buri M, Bolzinger MA, Chevalier Y, Riske KA, Ricci Leonardi G. Stabilization of vitamin C in emulsions of liquid crystalline structures. Int J Pharm. 2021 Jan 5;592:120092. doi: 10.1016/j.ijpharm.2020.120092. Epub 2020 Nov 16. PMID: 33212173. 11: Józsa L, Ujhelyi Z, Vasvári G, Sinka D, Nemes D, Fenyvesi F, Váradi J, Vecsernyés M, Szabó J, Kalló G, Vasas G, Bácskay I, Fehér P. Formulation of Creams Containing Spirulina Platensis Powder with Different Nonionic Surfactants for the Treatment of Acne Vulgaris. Molecules. 2020 Oct 21;25(20):4856. doi: 10.3390/molecules25204856. PMID: 33096785; PMCID: PMC7587940. 12: Notario-Pérez F, Martín-Illana A, Cazorla-Luna R, Ruiz-Caro R, Tamayo A, Rubio J, Veiga MD. Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV. Pharmaceutics. 2020 Apr 2;12(4):321. doi: 10.3390/pharmaceutics12040321. PMID: 32265431; PMCID: PMC7238131. 13: Vyas S, Khambete M, Gudhka R, Panchamia S, Degani M, Patravale V. Network topology of LMWG cross-linked xyloglucan hydrogels for embedding hydrophobic nanodroplets: mechanistic insight and molecular dynamics. Drug Deliv Transl Res. 2020 Aug;10(4):1076-1084. doi: 10.1007/s13346-020-00748-x. PMID: 32249369. 14: Penfield KW, Rumbelow S. Challenges in polysorbate characterization by mass spectrometry. Rapid Commun Mass Spectrom. 2020 Aug;34 Suppl 2:e8709. doi: 10.1002/rcm.8709. Epub 2020 Feb 8. PMID: 31943438. 15: Schwede K, Simon JC, Treudler R. A case of severe immediate type reaction to macrogol and polysorbate 60 after intravaginal drug application. Eur J Dermatol. 2019 Jun 1;29(3):329-331. doi: 10.1684/ejd.2019.3541. PMID: 31389792. 16: Tomić I, Juretić M, Jug M, Pepić I, Cetina Čižmek B, Filipović-Grčić J. Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study. Int J Pharm. 2019 May 30;563:249-258. doi: 10.1016/j.ijpharm.2019.04.016. Epub 2019 Apr 6. PMID: 30965120. 17: Mashal M, Attia N, Soto-Sánchez C, Martínez-Navarrete G, Fernández E, Puras G, Pedraz JL. Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain. Int J Pharm. 2018 Dec 1;552(1-2):48-55. doi: 10.1016/j.ijpharm.2018.09.038. Epub 2018 Sep 19. PMID: 30244145. 18: Zhang Z, Lunter DJ. Confocal Raman microspectroscopy as an alternative to differential scanning calorimetry to detect the impact of emulsifiers and formulations on stratum corneum lipid conformation. Eur J Pharm Sci. 2018 Aug 30;121:1-8. doi: 10.1016/j.ejps.2018.05.013. Epub 2018 May 22. PMID: 29775655. 19: Ikeuchi-Takahashi Y, Kobayashi A, Ishihara C, Matsubara T, Matsubara H, Onishi H. Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low- Saponification-Degree Polyvinyl Alcohol. Biol Pharm Bull. 2018;41(5):754-760. doi: 10.1248/bpb.b17-00964. PMID: 29709912. 20: Mashal M, Attia N, Puras G, Martínez-Navarrete G, Fernández E, Pedraz JL. Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60. J Control Release. 2017 May 28;254:55-64. doi: 10.1016/j.jconrel.2017.03.386. Epub 2017 Mar 24. PMID: 28347807.