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MedKoo Cat#: 462664 | Name: Maridomycin I

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Maridomycin I is a macrolide antibiotic.

Chemical Structure

Maridomycin I
Maridomycin I
CAS#35908-44-2

Theoretical Analysis

MedKoo Cat#: 462664

Name: Maridomycin I

CAS#: 35908-44-2

Chemical Formula: C43H71NO16

Exact Mass: 857.4773

Molecular Weight: 858.03

Elemental Analysis: C, 60.19; H, 8.34; N, 1.63; O, 29.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Platenomycin C3; Turimycin EP5;
IUPAC/Chemical Name
(E)-6-((4-(dimethylamino)-5-hydroxy-6-((13-hydroxy-8-methoxy-3,12-dimethyl-5-oxo-10-(2-oxoethyl)-7-(propionyloxy)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate
InChi Key
QGOYEYOBFDESQB-BUHFOSPRSA-N
InChi Code
InChI=1S/C43H71NO16/c1-12-32(47)57-31-20-34(49)53-24(5)19-30-29(56-30)14-13-28(46)23(4)18-27(15-16-45)39(40(31)52-11)60-42-37(50)36(44(9)10)38(25(6)55-42)59-35-21-43(8,51)41(26(7)54-35)58-33(48)17-22(2)3/h13-14,16,22-31,35-42,46,50-51H,12,15,17-21H2,1-11H3/b14-13+
SMILES Code
CCC(OC1CC(OC(CC2OC2/C=C/C(C(CC(C(C1OC)OC3OC(C(C(N(C)C)C3O)OC4CC(O)(C(C(O4)C)OC(CC(C)C)=O)C)C)CC=O)C)O)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 858.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kondo M, Oishi T, Tsuchiya K, Goto S, Kuwahara S. Maridomycin, a new macrolide antibiotic. In vitro antibacterial activity of 9-propionylmaridomycin. Antimicrob Agents Chemother. 1973 Aug;4(2):149-55. doi: 10.1128/aac.4.2.149. PMID: 4790935; PMCID: PMC444520. 2: Shibata M, Uyeda M, Mori S. I. Isolation and characterization of the transformation products of maridomycin III. J Antibiot (Tokyo). 1975 Jun;28(6):434-41. doi: 10.7164/antibiotics.28.434. PMID: 1150539. 3: Nakahama K, Kishi T, Igarasi S. Microbial conversion of antibiotics. 3. Hydroxylation of maridomycin I and josamycin. J Antibiot (Tokyo). 1974 Jun;27(6):433-41. doi: 10.7164/antibiotics.27.433. PMID: 4853208. 4: Kondo K. Analytical studies of maridomycin. I. High-performance liquid chromatography of marido-mycins and some other macrolide antibiotics. J Chromatogr. 1979 Feb 1;169:329-36. doi: 10.1016/0021-9673(75)85057-6. PMID: 536423. 5: Uyeda M, Mori S, Morita M, Ogata T, Mori M, Shibata M. Microbial transformation of antibiotics. III. Reacylation of 4"-depropionyl maridomycin III into maridomycin V (maridomycin K) by Streptomyces sp. strain no. K-342. J Antibiot (Tokyo). 1977 Dec;30(12):1130-1. doi: 10.7164/antibiotics.30.1130. PMID: 599088. 6: Shibata M, Uyeda M, Mori S. Microbial transformation of antibiotics II. Additional transformation products of maridomycin III. J Antibiot (Tokyo). 1976 Aug;29(8):824-8. doi: 10.7164/antibiotics.29.824. PMID: 993121. 7: Nakahama K, Izawa M, Muroi M, Kishi T, Uchida M. Microbial conversion of antibiotics. I. Deacylation of maridomycin by bacteria. J Antibiot (Tokyo). 1974 Jun;27(6):425-32. doi: 10.7164/antibiotics.27.425. PMID: 4212166. 8: Uyeda M, Kubota K, Miyamura S, Shibata M. Microbial transformation of maridomycin III by Serratia marcescens. J Antibiot (Tokyo). 1983 Dec;36(12):1722-8. doi: 10.7164/antibiotics.36.1722. PMID: 6363373. 9: Harada S, Muroi M, Kondo M, Tsuchiya K, Matsuzawa T. Chemical modification of maridomycin, a new macrolide antibiotic. Antimicrob Agents Chemother. 1973 Aug;4(2):140-8. doi: 10.1128/aac.4.2.140. PMID: 4790934; PMCID: PMC444519. 10: Ono H, Hasegawa T, Higashide E, Shibata M. Maridomycin, a new macrolide antibiotic. I. Taxonomy and fermentation. J Antibiot (Tokyo). 1973 Apr;26(4):191-8. doi: 10.7164/antibiotics.26.191. PMID: 4205650. 11: Muroi M, Izawa M, Asai M, Kishi T, Mizuno K. Maridomycin, a new macrolide antibiotic. II. Isolation and characterization. J Antibiot (Tokyo). 1973 Apr;26(4):199-205. doi: 10.7164/antibiotics.26.199. PMID: 4782048. 12: Muroi M, Izawa M, Kishi T. Maridomycin, a new macrolide antibiotic. 8. Isolation and structures of metabolites of 9-propionylmaridomycin. J Antibiot (Tokyo). 1974 Jun;27(6):449-59. doi: 10.7164/antibiotics.27.449. PMID: 4853097. 13: Kondo M, Oishi T, Ishifuji K, Tsuchiya K. Maridomycin, a new macrolide antibiotic. 3. In vitro and in vivo antibacterial activity. J Antibiot (Tokyo). 1973 Apr;26(4):206-14. doi: 10.7164/antibiotics.26.206. PMID: 4782049. 14: Kondo M, Ishifuji K, Tsuchiya K, Goto S, Kuwahara S. Maridomycin, a new macrolide antibiotic: in vivo antibacterial activity of 9-propionylmaridomycin. Antimicrob Agents Chemother. 1973 Aug;4(2):156-9. doi: 10.1128/aac.4.2.156. PMID: 4790936; PMCID: PMC444521. 15: Muroi M, Izawa M, Kishi T. Maridomycin, a new macrolide antibiotic. X. The structure of maridomycin II. Chem Pharm Bull (Tokyo). 1976 Mar;24(3):450-62. doi: 10.1248/cpb.24.450. PMID: 1021251. 16: Ono H, Harada S, Kishi T. Maridomycin, a new macrolide antibiotic. VII. Incorporation of labeled precursors into maridomycin and preparation of 14C-labeled 9-propionylmaridomycin. J Antibiot (Tokyo). 1974 Jun;27(6):442-8. PMID: 4853096. 17: Muroi M, Izawa M, Kishi T. Maridomycin, a new macrolide antibiotic. XI. The structures of maridomycin components. Chem Pharm Bull (Tokyo). 1976 Mar;24(3):463-78. doi: 10.1248/cpb.24.463. PMID: 1021252. 18: Nakahama K, Igarasi S. Microbial conversion of antibiotics. IV. Reduction of maridomycin. J Antibiot (Tokyo). 1974 Aug;27(8):605-9. doi: 10.7164/antibiotics.27.605. PMID: 4436146. 19: Nakahama K, Kishi T, Igarasi S. Letter: Microbial conversion of antibiotics. II. Deacylation of maridomycin by Actinomycetes. J Antibiot (Tokyo). 1974 Jun;27(6):487-8. doi: 10.7164/antibiotics.27.487. PMID: 4852860. 20: Muroi M, Izawa M, Ono H, Higashide E, Kishi T. Isolation of maridomycins and structure of maridomycin II. Experientia. 1972 Aug 15;28(8):878-80. doi: 10.1007/BF01924916. PMID: 5076309.

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UNBS5162

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