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MedKoo Cat#: 330042 | Name: Mefentrifluconazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mefentrifluconazole is a fungicide on cereals.

Chemical Structure

Mefentrifluconazole
Mefentrifluconazole
CAS#1417782-03-6

Theoretical Analysis

MedKoo Cat#: 330042

Name: Mefentrifluconazole

CAS#: 1417782-03-6

Chemical Formula: C18H15ClF3N3O2

Exact Mass: 397.0805

Molecular Weight: 397.78

Elemental Analysis: C, 54.35; H, 3.80; Cl, 8.91; F, 14.33; N, 10.56; O, 8.04

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Mefentrifluconazole; BAS 750 F; BAS 750F; BAS750F;
IUPAC/Chemical Name
2-(4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol
InChi Key
JERZEQUMJNCPRJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H15ClF3N3O2/c1-17(26,9-25-11-23-10-24-25)15-7-6-14(8-16(15)18(20,21)22)27-13-4-2-12(19)3-5-13/h2-8,10-11,26H,9H2,1H3
SMILES Code
CC(O)(C1=CC=C(OC2=CC=C(Cl)C=C2)C=C1C(F)(F)F)CN3N=CN=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM).
In vitro activity:
In this study, the DMI fungicide mefentrifluconazole exhibited excellent inhibitory activity against the mycelial growth of S. rolfsii, with a mean EC50 value of 0.21 ± 0.11 mg L-1 and a range of 0.02 to 0.55 mg L-1 for 261 isolates collected from Hebei, Henan and Shandong provinces. Mefentrifluconazole significantly reduced the biomass of mycelia and affected the morphology of hyphae. Reference: Pest Manag Sci. 2023 Jan 29. https://pubmed.ncbi.nlm.nih.gov/36710267/
In vivo activity:
The 96-h lethal concentration 50 (LC50) values (exposed to racemate and enantiomers of MFZ (mefentrifluconazole), that is, rac-MFZ/(-)-MFZ/(+)-MFZ) were 1.010, 1.552, and 0.753 mg/L for embryo, and 0.753, 1.187, and 0.553 mg/L for larvae. The rac-MFZ/(-)-MFZ/(+)-MFZ can affect the heart development of zebrafish embryos, accompanied by heart rate inhibition, yolk sac deformities, pericardial deformities, and down-regulation of genes related to cardiotoxicity in larvae in an enantioselective manner. Moreover, the rac-MFZ/(-)-MFZ/(+)-MFZ also can affect the neural development of zebrafish embryos, accompanied by autonomic movement inhibition, swimming speed and swimming distance abnormalities, and down-regulation of genes related to neurotoxicity in larvae in an enantioselective manner. Reference: Environ Toxicol. 2022 Jul;37(7):1662-1674. https://pubmed.ncbi.nlm.nih.gov/35297557/
Solvent mg/mL mM
Solubility
DMSO 100.0 251.39
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 397.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Han Z, Cui K, Wang M, Jiang C, Zhao T, Wang M, Du P, He L, Zhou L. Bioactivity of the DMI fungicide mefentrifluconazole against Sclerotium rolfsii, the causal agent of peanut southern blight. Pest Manag Sci. 2023 Jan 29. doi: 10.1002/ps.7386. Epub ahead of print. PMID: 36710267. 2. Liu Y, Ma T, Dong Y, Mao C, Wu J, Zhang C. Bioactivity of mefentrifluconazole against different Fusarium spp. Pestic Biochem Physiol. 2022 Aug;186:105169. doi: 10.1016/j.pestbp.2022.105169. Epub 2022 Jul 6. PMID: 35973774. 3. Li Y, Ren B, Zhao T, Chen H, Zhao Y, Liang H, Liang H. Enantioselective toxic effects of mefentrifluconazole in the early life stage of zebrafish (Danio rerio). Environ Toxicol. 2022 Jul;37(7):1662-1674. doi: 10.1002/tox.23515. Epub 2022 Mar 16. PMID: 35297557. 4. Li Y, Liang H, Ren B, Zhao T, Chen H, Zhao Y, Liang H. Enantioselective toxic effects of mefentrifluconazole in the liver of adult zebrafish (Danio rerio) based on transcription level and metabolomic profile. Toxicology. 2022 Feb 15;467:153095. doi: 10.1016/j.tox.2022.153095. Epub 2022 Jan 6. PMID: 34999168.
In vitro protocol:
1. Han Z, Cui K, Wang M, Jiang C, Zhao T, Wang M, Du P, He L, Zhou L. Bioactivity of the DMI fungicide mefentrifluconazole against Sclerotium rolfsii, the causal agent of peanut southern blight. Pest Manag Sci. 2023 Jan 29. doi: 10.1002/ps.7386. Epub ahead of print. PMID: 36710267. 2. Liu Y, Ma T, Dong Y, Mao C, Wu J, Zhang C. Bioactivity of mefentrifluconazole against different Fusarium spp. Pestic Biochem Physiol. 2022 Aug;186:105169. doi: 10.1016/j.pestbp.2022.105169. Epub 2022 Jul 6. PMID: 35973774.
In vivo protocol:
1. Li Y, Ren B, Zhao T, Chen H, Zhao Y, Liang H, Liang H. Enantioselective toxic effects of mefentrifluconazole in the early life stage of zebrafish (Danio rerio). Environ Toxicol. 2022 Jul;37(7):1662-1674. doi: 10.1002/tox.23515. Epub 2022 Mar 16. PMID: 35297557. 2. Li Y, Liang H, Ren B, Zhao T, Chen H, Zhao Y, Liang H. Enantioselective toxic effects of mefentrifluconazole in the liver of adult zebrafish (Danio rerio) based on transcription level and metabolomic profile. Toxicology. 2022 Feb 15;467:153095. doi: 10.1016/j.tox.2022.153095. Epub 2022 Jan 6. PMID: 34999168.
1: Zhang Y, Wu X, Li X, Duan T, Xu J, Dong F, Liu X, Guo L, Zheng Y. A fast and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry method for determining mefentrifluconazole in plant- and animal-derived foods. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Sep;36(9):1348-1357. doi: 10.1080/19440049.2019.1628361. Epub 2019 Jul 9. PMID: 31287378. 2: European Food Safety Authority (EFSA), Arena M, Auteri D, Barmaz S, Brancato A, Brocca D, Bura L, Carrasco Cabrera L, Chiusolo A, Civitella C, Court Marques D, Crivellente F, Ctverackova L, De Lentdecker C, Egsmose M, Erdos Z, Fait G, Ferreira L, Goumenou M, Greco L, Ippolito A, Istace F, Jarrah S, Kardassi D, Leuschner R, Lythgo C, Magrans JO, Medina P, Mineo D, Miron I, Molnar T, Padovani L, Parra Morte JM, Pedersen R, Reich H, Riemenschneider C, Sacchi A, Santos M, Serafimova R, Sharp R, Stanek A, Streissl F, Sturma J, Szentes C, Tarazona J, Terron A, Theobald A, Vagenende B, Van Dijk J, Villamar-Bouza L. Peer review of the pesticide risk assessment of the active substance BAS 750 F (mefentrifluconazole). EFSA J. 2018 Jul 25;16(7):e05379. doi: 10.2903/j.efsa.2018.5379. PMID: 32626002; PMCID: PMC7009668. 3: Tesh SA, Tesh JM, Fegert I, Buesen R, Schneider S, Mentzel T, van Ravenzwaay B, Stinchcombe S. Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol®) and the impact upon its toxicity profile. Regul Toxicol Pharmacol. 2019 Aug;106:152-168. doi: 10.1016/j.yrtph.2019.04.009. Epub 2019 Apr 24. PMID: 31026541. 4: European Food Safety Authority (EFSA), Anastassiadou M, Bernasconi G, Brancato A, Carrasco Cabrera L, Ferreira L, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Reich H, Rojas A, Sacchi A, Santos M, Stanek A, Theobald A, Vagenende B, Verani A. Modification and setting of maximum residue levels for mefentrifluconazole in various crops. EFSA J. 2020 Jul 27;18(7):e06193. doi: 10.2903/j.efsa.2020.6193. PMID: 32728398; PMCID: PMC7384233. 5: Li J, Dong C, An W, Zhang Y, Zhao Q, Li Z, Jiao B. Simultaneous Enantioselective Determination of Two New Isopropanol-Triazole Fungicides in Plant-Origin Foods Using Multiwalled Carbon Nanotubes in Reversed-Dispersive Solid-Phase Extraction and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry. J Agric Food Chem. 2020 May 27;68(21):5969-5979. doi: 10.1021/acs.jafc.0c01385. Epub 2020 May 12. PMID: 32347725.