5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties. It is cytotoxic to KB, A549, and HCT-8 cells. It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1. However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.
MedKoo Cat#: 462645
Name: 5-Methoxycanthinone
CAS#: 15071-56-4
Chemical Formula: C15H10N2O2
Exact Mass: 250.0742
Molecular Weight: 250.26
Elemental Analysis: C, 71.99; H, 4.03; N, 11.19; O, 12.79
The following data is based on the product molecular weight 250.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
