Synonym
T-544 toxin; Tullidinol;
IUPAC/Chemical Name
3,8,9-trihydroxy-7-(10-hydroxy-7,9-dimethoxy-1,3-dimethyl-3,4-dihydro-1H-benzo[g]isochromen-5-yl)-3-methyl-3,4-dihydroanthracen-1(2H)-one
InChi Key
OFXNQLFWWFUNRK-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H32O8/c1-14-8-20-24(15(2)40-14)30(35)28-21(10-18(38-4)11-23(28)39-5)27(20)19-7-6-16-9-17-12-32(3,37)13-22(33)25(17)31(36)26(16)29(19)34/h6-7,9-11,14-15,34-37H,8,12-13H2,1-5H3
SMILES Code
COc(cc1OC)cc2c1c(O)c(C(OC(C3)C)C)c3c2c(cc4)c(O)c5c4cc(CC(O)(CC6=O)C)c6c5O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
544.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Garza-Ocañas L, Hsieh GC, Acosta D, Torres-Alanís O, Piñeyro-López A. Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Toxicology. 1992;73(3):259-67. doi: 10.1016/0300-483x(92)90068-p. PMID: 1631903.
2: Garza-Ocañas L, Hsieh GC, Acosta D, Torres-Alanís O, Piñeyro-López A. Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Toxicology. 1992;73(2):191-201. doi: 10.1016/0300-483x(92)90102-k. PMID: 1609429.
3: Salazar-Aranda R, Sepúlveda-Saavedra J, Waksman de Torres N, Piñeyro-López A, Moreno-Sepúlveda M. Effect of peroxisomicine A2 and T 544 of the genus Karwinskia on peroxisomes of Candida boidinii. FEMS Microbiol Lett. 1998 Jan 15;158(2):255-60. doi: 10.1111/j.1574-6968.1998.tb12829.x. PMID: 9465396.
4: Valadez-Alvizo R, Rodríguez-Alvarado A, Martínez de Villarreal L, González- Alanís R, Piñeyro-López A. Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse. Toxicon. 1993 Oct;31(10):1329-32. doi: 10.1016/0041-0101(93)90406-9. PMID: 8303727.
5: Waksman N, Benavides-Cortez G, Rivas-Galindo V. Biologically active anthracenones from roots of Karwinskia parvifolia. Phytochemistry. 1999 Mar;50(6):1041-6. doi: 10.1016/s0031-9422(98)00587-1. PMID: 10419282.
6: Moreno-Sepúlveda M, Vargas-Zapata R, Ballesteros-Elizondo R, Piñeyro-López A, Sepúlveda-Saavedra J. Studies on the effect of peroxisomicine on catalase activity in albino mice. Toxicon. 1997 May;35(5):777-83. doi: 10.1016/s0041-0101(96)00164-x. PMID: 9203303.
7: Muñoz-Martínez EJ, Cuéllar-Pedroza LH, Rubio-Franchini C, Jáuregui-Rincón J, Joseph-Nathan P. Depression of fast axonal transport in axons demyelinated by intraneural injection of a neurotoxin from K. humboldtiana. Neurochem Res. 1994 Nov;19(11):1341-8. doi: 10.1007/BF00972461. PMID: 7534872.
