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MedKoo Cat#: 462613 | Name: IACS-9439

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IACS-9439 is a potent, highly selective,and orally bioavailable CSF1R inhibitor. Treatment with IACS-9439 led to a dose-dependent reduction in macrophages,promoted macrophage polarization toward the M1 phenotype, and led to tumor growth inhibition in MC38 and PANC02 syngeneic tumor models.

Chemical Structure

IACS-9439
IACS-9439
CAS#2231259-57-5

Theoretical Analysis

MedKoo Cat#: 462613

Name: IACS-9439

CAS#: 2231259-57-5

Chemical Formula: C23H26ClN7O3S

Exact Mass: 515.1506

Molecular Weight: 516.02

Elemental Analysis: C, 53.54; H, 5.08; Cl, 6.87; N, 19.00; O, 9.30; S, 6.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
IACS-9439; IACS9439; IACS 9439
IUPAC/Chemical Name
(1S,2S)-2-((7-chloro-4-methoxy-6-((2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)methoxy)benzo[d]thiazol-2-yl)amino)cyclohexan-1-ol
InChi Key
JYFJGEOXSQLPMB-HOTGVXAUSA-N
InChi Code
InChI=1S/C23H26ClN7O3S/c1-31-11-14(10-26-31)28-22-25-8-7-13(27-22)12-34-17-9-18(33-2)20-21(19(17)24)35-23(30-20)29-15-5-3-4-6-16(15)32/h7-11,15-16,32H,3-6,12H2,1-2H3,(H,29,30)(H,25,27,28)/t15-,16-/m0/s1
SMILES Code
O[C@@H]1[C@@H](NC2=NC3=C(OC)C=C(OCC4=NC(NC5=CN(C)N=C5)=NC=C4)C(Cl)=C3S2)CCCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 516.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Czako B, Marszalek JR, Burke JP, Mandal P, Leonard PG, Cross JB, Mseeh F, Jiang Y, Chang EQ, Suzuki E, Kovacs JJ, Feng N, Gera S, Harris AL, Liu Z, Mullinax RA, Pang J, Parker CA, Spencer ND, Yu SS, Wu Q, Tremblay MR, Mikule K, Wilcoxen K, Heffernan TP, Draetta GF, Jones P. Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R. J Med Chem. 2020 Aug 18. doi: 10.1021/acs.jmedchem.0c00936. Epub ahead of print. PMID: 32787110.