STC4 | CAS#N/A

MedKoo Cat#: 535247 | Name: STC4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

STC4 is a novel isoform 2 of Sirtuins (SIRT2) inhibitor.

Chemical Structure

STC4

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 535247

Name: STC4

CAS#: N/A

Chemical Formula: C31H33N3O2S

Exact Mass: 511.2293

Molecular Weight: 511.68

Elemental Analysis: C, 72.77; H, 6.50; N, 8.21; O, 6.25; S, 6.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

STC4; STC-4; STC 4

IUPAC/Chemical Name

Methyl N-((4-(dimethylamino)pyridin-2-yl)methyl)-S-trityl-D-cysteinate

InChi Key

YTMIPMRQFGIODS-GDLZYMKVSA-N

InChi Code

InChI=1S/C31H33N3O2S/c1-34(2)28-19-20-32-27(21-28)22-33-29(30(35)36-3)23-37-31(24-13-7-4-8-14-24,25-15-9-5-10-16-25)26-17-11-6-12-18-26/h4-21,29,33H,22-23H2,1-3H3/t29-/m1/s1

SMILES Code

O=C(OC)[C@@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)NCC4=NC=CC(N(C)C)=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 511.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Radwan MO, Ciftci HI, Ali TFS, Ellakwa DE, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Okamoto Y, Fujita M, Otsuka M. Antiproliferative S-Trityl- l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement. Molecules. 2019 Sep 10;24(18):3295. doi: 10.3390/molecules24183295. PMID: 31510043; PMCID: PMC6766826. 2: Radwan MO, Ciftci HI, Ali TFS, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Fujita M, Otsuka M. Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition. Bioorg Med Chem Lett. 2020 Aug 2;30(19):127458. doi: 10.1016/j.bmcl.2020.127458. Epub ahead of print. PMID: 32755678. 3: Kang MC, Ding Y, Kim EA, Choi YK, de Araujo T, Heo SJ, Lee SH. Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes. Mar Drugs. 2017 Apr 12;15(4):119. doi: 10.3390/md15040119. PMID: 28417922; PMCID: PMC5408265.