MedKoo Cat#: 535245 | Name: KYN-101
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KYN-101 is a novel potent and selective inhibitor of aryl hydrocarbon receptor (AHR) (IC50 of 22 nM in the human HepG2 DRE-luciferase reporter assay and 23 nM in the murine Hepa1 Cyp-luc assay).

Chemical Structure

KYN-101
KYN-101
CAS#2247950-73-6

Theoretical Analysis

MedKoo Cat#: 535245

Name: KYN-101

CAS#: 2247950-73-6

Chemical Formula: C22H19FN6

Exact Mass: 386.1655

Molecular Weight: 386.43

Elemental Analysis: C, 68.38; H, 4.96; F, 4.92; N, 21.75

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
KYN-101; KYN 101; KYN101
IUPAC/Chemical Name
N-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine
InChi Key
XIBYMKUWLQLNLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H19FN6/c1-14-10-27-29-21(9-20(28-22(14)29)16-8-17(23)13-24-11-16)25-7-6-15-12-26-19-5-3-2-4-18(15)19/h2-5,8-13,25-26H,6-7H2,1H3
SMILES Code
CC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ding Y, Chen L, Xu J, Liu Q. NR2E3 inhibits the inflammation and apoptosis in diabetic retinopathy by regulating the AHR/IL-17A signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov;397(11):9081-9094. doi: 10.1007/s00210-024-03213-5. Epub 2024 Jun 17. PMID: 38884674. 2: Diedrich JD, Gonzalez-Pons R, Medeiros HCD, Ensink E, Liby KT, Wellberg EA, Lunt SY, Bernard JJ. Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor. Biochem Pharmacol. 2023 Oct;216:115763. doi: 10.1016/j.bcp.2023.115763. Epub 2023 Aug 23. PMID: 37625554; PMCID: PMC10587895.