Synonym
Chromanol 293B; Chromanol 239B; (-)-[3R,4S]-Chromanol 293B; 293B Cpd; (-)-Chromanol 293B
IUPAC/Chemical Name
rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
InChi Key
HVSJHHXUORMCGK-UONOGXRCSA-N
InChi Code
InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
SMILES Code
CC1(C)[C@H](O)[C@@H](N(S(CC)(=O)=O)C)C2=C(C=CC(C#N)=C2)O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Suessbrich, H., Bleich, M., Ecke, D., et al. Specific blockade of slowly activating IsK channels by chromanols -- Impact on the role of IsK channels in epithelia. FEBS Lett. 396(2-3), 271-275 (1996).
2. Fujisawa, S., K., O., and Iijima, T. Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br. J. Pharmacol. 129(5), 1007-1013 (2000).
3. Bachmann, A., Quast, U., and Russ, U. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch. Pharmacol. 363(6), 590-596 (2001).