MedKoo Cat#: 574630 | Name: Chromanol 293B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) that increases the rate and extent of IKs in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR).

Chemical Structure

Chromanol 293B
Chromanol 293B
CAS#163163-23-3

Theoretical Analysis

MedKoo Cat#: 574630

Name: Chromanol 293B

CAS#: 163163-23-3

Chemical Formula: C15H20N2O4S

Exact Mass: 324.1144

Molecular Weight: 324.39

Elemental Analysis: C, 55.54; H, 6.21; N, 8.64; O, 19.73; S, 9.88

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Chromanol 293B; Chromanol 239B; (-)-[3R,4S]-Chromanol 293B; 293B Cpd; (-)-Chromanol 293B
IUPAC/Chemical Name
rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
InChi Key
HVSJHHXUORMCGK-UONOGXRCSA-N
InChi Code
InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
SMILES Code
CC1(C)[C@H](O)[C@@H](N(S(CC)(=O)=O)C)C2=C(C=CC(C#N)=C2)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Suessbrich, H., Bleich, M., Ecke, D., et al. Specific blockade of slowly activating IsK channels by chromanols -- Impact on the role of IsK channels in epithelia. FEBS Lett. 396(2-3), 271-275 (1996). 2. Fujisawa, S., K., O., and Iijima, T. Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br. J. Pharmacol. 129(5), 1007-1013 (2000). 3. Bachmann, A., Quast, U., and Russ, U. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch. Pharmacol. 363(6), 590-596 (2001).