MedKoo Cat#: 462580 | Name: IPI-9119
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IPI-9119 is an orally active, selective and irreversible FASN inhibitor. It inhibits tumor growth of castration-resistant prostate cancer (CRPC) xenografts mouse models.

Chemical Structure

IPI-9119
IPI-9119
CAS#1346564-56-4

Theoretical Analysis

MedKoo Cat#: 462580

Name: IPI-9119

CAS#: 1346564-56-4

Chemical Formula: C24H19F2N5O5

Exact Mass: 495.1354

Molecular Weight: 495.44

Elemental Analysis: C, 58.18; H, 3.87; F, 7.67; N, 14.14; O, 16.15

Price and Availability

Size Price Availability Quantity
5mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
IPI-9119; IPI 9119; IPI9119
IUPAC/Chemical Name
4-(4-(2,6-difluorophenyl)-N-isopropyl-5-oxo-4,5-dihydro-1H-tetrazole-1-carboxamido)-3-phenoxybenzoic acid
InChi Key
VYXOFKWKPKVNID-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H19F2N5O5/c1-14(2)29(19-12-11-15(22(32)33)13-20(19)36-16-7-4-3-5-8-16)23(34)31-24(35)30(27-28-31)21-17(25)9-6-10-18(21)26/h3-14H,1-2H3,(H,32,33)
SMILES Code
O=C(O)C1=CC=C(N(C(N2N=NN(C3=C(F)C=CC=C3F)C2=O)=O)C(C)C)C(OC4=CC=CC=C4)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zadra G, Ribeiro CF, Chetta P, et al. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2019;116(2):631-640. doi:10.1073/pnas.1808834116 2: Erin Broph, et al. Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119.