MedKoo Cat#: 574624 | Name: CGS-35066
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGS-35066 is an endothelin-converting enzyme (ECE) inhibitor that blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Chemical Structure

CGS-35066
CGS-35066
CAS# 261619-50-5

Theoretical Analysis

MedKoo Cat#: 574624

Name: CGS-35066

CAS#: 261619-50-5

Chemical Formula: C16H16NO6P

Exact Mass: 349.0715

Molecular Weight: 349.28

Elemental Analysis: C, 55.02; H, 4.62; N, 4.01; O, 27.48; P, 8.87

Price and Availability

Size Price Availability Quantity
10mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
CGS 35066; CGS-35066; CGS35066
IUPAC/Chemical Name
(S)-3-(dibenzo[b,d]furan-3-yl)-2-((phosphonomethyl)amino)propanoic acid
InChi Key
CRUVAUSVWLATAE-ZDUSSCGKSA-N
InChi Code
InChI=1S/C16H16NO6P/c18-16(19)13(17-9-24(20,21)22)7-10-5-6-12-11-3-1-2-4-14(11)23-15(12)8-10/h1-6,8,13,17H,7,9H2,(H,18,19)(H2,20,21,22)/t13-/m0/s1
SMILES Code
O=C(O)[C@@H](NCP(O)(O)=O)CC1=CC=C2C(OC3=CC=CC=C23)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. De Lombaert et al (2000) Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 43 488 PMID: 10669576 2. Trapani et al (2000) Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J.Cardiovasc.Pharmacol. 36 S40 PMID: 11078331 3. Kwan et al (2002) Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuropharmacol.Neurotoxicol. 13 197