RhlR antagonist 30 | CAS#N/A

MedKoo Cat#: 535222 | Name: RhlR antagonist 30

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RhlR antagonist 30 is a novel potent and selective RhlR antagonist, strongly inhibiting biofilm formation, and reducing production of virulence factors in P. aeruginosa.

Chemical Structure

RhlR antagonist 30

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 535222

Name: RhlR antagonist 30

CAS#: N/A

Chemical Formula: C12H10F2O

Exact Mass: 208.0700

Molecular Weight: 208.21

Elemental Analysis: C, 69.23; H, 4.84; F, 18.25; O, 7.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RhlR antagonist 30

IUPAC/Chemical Name

1-(3,4-Difluorophenyl)hex-1-yn-3-one

InChi Key

XNIUHFANKOJONW-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H10F2O/c1-2-3-10(15)6-4-9-5-7-11(13)12(14)8-9/h5,7-8H,2-3H2,1H3

SMILES Code

CCCC(C#CC1=CC=C(F)C(F)=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 208.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nam S, Ham SY, Kwon H, Kim HS, Moon S, Lee JH, Lim T, Son SH, Park HD, Byun Y. Discovery and characterization of pure RhlR antagonists against Pseudomonas aeruginosa infections. J Med Chem. 2020 Jul 22. doi: 10.1021/acs.jmedchem.0c00630. Epub ahead of print. PMID: 32696644. 2: Banerjee J, Das Ghatak P, Roy S, Khanna S, Hemann C, Deng B, Das A, Zweier JL, Wozniak D, Sen CK. Silver-zinc redox-coupled electroceutical wound dressing disrupts bacterial biofilm. PLoS One. 2015 Mar 24;10(3):e0119531. doi: 10.1371/journal.pone.0119531. PMID: 25803639; PMCID: PMC4372374.