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MedKoo Cat#: 535212 | Name: SCO-267

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCO-267 is a novel GPR40 full agonist, improving liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight.

Chemical Structure

SCO-267
SCO-267
CAS#1656261-09-4

Theoretical Analysis

MedKoo Cat#: 535212

Name: SCO-267

CAS#: 1656261-09-4

Chemical Formula: C36H46N4O5

Exact Mass: 614.3468

Molecular Weight: 614.79

Elemental Analysis: C, 70.33; H, 7.54; N, 9.11; O, 13.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SCO-267;SCO 267; SCO267
IUPAC/Chemical Name
(S)-3-Cyclopropyl-3-(2-((1-(5-methoxy-2-((6-methylpyridin-2-yl)(neopentyl)carbamoyl)phenyl)piperidin-4-yl)methoxy)pyridin-4-yl)propanoic acid
InChi Key
VVRXREQIOCYUKN-PMERELPUSA-N
InChi Code
InChI=1S/C36H46N4O5/c1-24-7-6-8-32(38-24)40(23-36(2,3)4)35(43)29-12-11-28(44-5)20-31(29)39-17-14-25(15-18-39)22-45-33-19-27(13-16-37-33)30(21-34(41)42)26-9-10-26/h6-8,11-13,16,19-20,25-26,30H,9-10,14-15,17-18,21-23H2,1-5H3,(H,41,42)/t30-/m0/s1
SMILES Code
O=C(O)C[C@@H](C1CC1)C2=CC(OCC3CCN(C4=CC(OC)=CC=C4C(N(C5=NC(C)=CC=C5)CC(C)(C)C)=O)CC3)=NC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 614.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ueno H, Ito R, Abe SI, Ookawara M, Miyashita H, Ogino H, Miyamoto Y, Yoshihara T, Kobayashi A, Tsujihata Y, Takeuchi K, Watanabe M, Yamada Y, Maekawa T, Nishigaki N, Moritoh Y. SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity. J Pharmacol Exp Ther. 2019 Aug;370(2):172-181. doi: 10.1124/jpet.118.255885. Epub 2019 Jun 10. PMID: 31182471. 2: Ookawara M, Matsuda K, Watanabe M, Moritoh Y. The GPR40 full agonist SCO-267 improves liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight. J Pharmacol Exp Ther. 2020 Jul 27:JPET-AR-2020-000046. doi: 10.1124/jpet.120.000046. Epub ahead of print. PMID: 32719069.