MedKoo Cat#: 574605 | Name: CPNQ
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

B2, also known as CPNQ, is a biochemical that promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. B2 prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Chemical Structure

CPNQ
CPNQ
CAS# 115687-05-3

Theoretical Analysis

MedKoo Cat#: 574605

Name: CPNQ

CAS#: 115687-05-3

Chemical Formula: C20H17ClN4O3

Exact Mass: 396.0989

Molecular Weight: 396.83

Elemental Analysis: C, 60.53; H, 4.32; Cl, 8.93; N, 14.12; O, 12.10

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
50mg USD 650.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
B2; B 2; B-2; CPNQ; SIRT2-IN-8
IUPAC/Chemical Name
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
InChi Key
KLNPVNZJCWIQSK-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2
SMILES Code
O=[N+](C1=C2N=CC=CC2=C(N3CCN(C(C4=CC=C(Cl)C=C4)=O)CC3)C=C1)[O-]
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 396.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bodner et al (2006) Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases. Proc.Natl.Acad.Sci.USA 103 4246