BML-286 is a cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain of Dvl, blocking Wnt3a-induced transcription activity, and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells. BML-286 has been shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection in vivo.
MedKoo Cat#: 574598
Name: BML-286
CAS#: 294891-81-9
Chemical Formula: C22H18N2O4
Exact Mass: 374.1267
Molecular Weight: 374.40
Elemental Analysis: C, 70.58; H, 4.85; N, 7.48; O, 17.09
The following data is based on the product molecular weight 374.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
