MedKoo Cat#: 462522 | Name: VH032-PEG1-N3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH032-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.

Chemical Structure

VH032-PEG1-N3
VH032-PEG1-N3
CAS#2101200-09-1

Theoretical Analysis

MedKoo Cat#: 462522

Name: VH032-PEG1-N3

CAS#: 2101200-09-1

Chemical Formula: C26H35N7O5S

Exact Mass: 557.2420

Molecular Weight: 557.67

Elemental Analysis: C, 56.00; H, 6.33; N, 17.58; O, 14.34; S, 5.75

Price and Availability

Size Price Availability Quantity
100mg USD 740.00 2 Weeks
500mg USD 2,240.00 2 Weeks
1g USD 3,800.00 2 Weeks
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Related CAS #
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Synonym
VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; (S,R,S)-AHPC-PEG1-N3; E3 ligase Ligand-Linker Conjugates 3
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-(2-(2-azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key
YVCURZJBLHZABY-ZRCGQRJVSA-N
InChi Code
InChI=1S/C26H35N7O5S/c1-16-22(39-15-29-16)18-7-5-17(6-8-18)12-28-24(36)20-11-19(34)13-33(20)25(37)23(26(2,3)4)31-21(35)14-38-10-9-30-32-27/h5-8,15,19-20,23,34H,9-14H2,1-4H3,(H,28,36)(H,31,35)/t19-,20+,23-/m1/s1
SMILES Code
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCN=[N+]=[N-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 557.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang, Huibin., Et al. Bifunctional molecule based on VHL ligand induced BET degradation as well as preparation and application thereof. CN106749513A.