Sivopixant, also known as S-600918, is a selective P2X3 receptor antagonist (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant showed a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg).
MedKoo Cat#: 462505
Name: Sivopixant
CAS#: 2414285-40-6
Chemical Formula: C25H22ClN5O5
Exact Mass: 507.1309
Molecular Weight: 507.93
Elemental Analysis: C, 59.12; H, 4.37; Cl, 6.98; N, 13.79; O, 15.75
The following data is based on the product molecular weight 507.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
