MMH409 is a novel potent and selective HDAC8 inhibitor. MMH409 exhibits potent in vitro HDAC8 activity (IC50 = 66 nM) and up to 410-fold selectivity for HDAC8 over the next targeted HDAC. Experimental and computational analyses of the benzanilide structure docked with human HDAC8 enzyme showed the adoption of a low-energy L-shaped conformer that favors HDAC8 selectivity. The conformationally constrained HDAC8 inhibitors present an alternative biological probe for further determining the clinical utility and safety of pharmacological knockdown of HDAC8 in diseased cells.
MedKoo Cat#: 535174
Name: MMH409
CAS#: 2704554-86-7
Chemical Formula: C19H16F6N2O3
Exact Mass: 434.1065
Molecular Weight: 434.34
Elemental Analysis: C, 52.54; H, 3.71; F, 26.24; N, 6.45; O, 11.05
The following data is based on the product molecular weight 434.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
