MedKoo Cat#: 462498 | Name: DGY-06-116
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DGY-06-116 is an irreversible covalent, selective Src inhibitor.

Chemical Structure

DGY-06-116
CAS#2556836-50-9

Theoretical Analysis

MedKoo Cat#: 462498

Name: DGY-06-116

CAS#: 2556836-50-9

Chemical Formula: C32H33ClN8O2

Exact Mass: 596.2415

Molecular Weight: 597.12

Elemental Analysis: C, 64.37; H, 5.57; Cl, 5.94; N, 18.77; O, 5.36

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,250.00 2 Weeks
2g USD 5,650.00 2 Weeks
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Related CAS #
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Synonym
DGY-06-116; DGY 06 116; DGY 06-116; DGY-06 116
IUPAC/Chemical Name
4-((2-acrylamidophenyl)amino)-N-(2-chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide
InChi Key
HLRQYOGLZWIOPA-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H33ClN8O2/c1-4-28(42)36-26-10-5-6-11-27(26)37-30-24(31(43)38-29-21(2)8-7-9-25(29)33)20-34-32(39-30)35-22-12-14-23(15-13-22)41-18-16-40(3)17-19-41/h4-15,20H,1,16-19H2,2-3H3,(H,36,42)(H,38,43)(H2,34,35,37,39)
SMILES Code
O=C(NC1=C(Cl)C=CC=C1C)C(C=N2)=C(NC3=C(NC(C=C)=O)C=CC=C3)N=C2NC4=CC=C(N5CCN(C)CC5)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 597.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Du G, Rao S, Gurbani D, et al. Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine. J Med Chem. 2020;63(4):1624-1641. doi:10.1021/acs.jmedchem.9b01502 2: Gurbani D, Du G, Henning NJ, et al. Structure and Characterization of a Covalent Inhibitor of Src Kinase. Front Mol Biosci. 2020;7:81. Published 2020 May 19. doi:10.3389/fmolb.2020.00081