MedKoo Cat#: 462496 | Name: K00546
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

K00546 is a potent CDK1 and CDK2 inhibitor and is a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor

Chemical Structure

K00546
K00546
CAS#443798-47-8

Theoretical Analysis

MedKoo Cat#: 462496

Name: K00546

CAS#: 443798-47-8

Chemical Formula: C15H13F2N7O2S2

Exact Mass: 425.0540

Molecular Weight: 425.43

Elemental Analysis: C, 42.35; H, 3.08; F, 8.93; N, 23.05; O, 7.52; S, 15.07

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
10mg USD 900.00 2 Weeks
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Related CAS #
No Data
Synonym
K00546; K 00546; K-00546
IUPAC/Chemical Name
5-amino-N-(2,6-difluorophenyl)-3-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide
InChi Key
ARIOBGGRZJITQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
SMILES Code
S=C(N1N=C(NC2=CC=C(S(=O)(N)=O)C=C2)N=C1N)NC3=C(F)C=CC=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 425.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pike AC, Rellos P, Niesen FH, et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008;27(4):704-714. doi:10.1038/emboj.2008.8 2: Fedorov O, Huber K, Eisenreich A, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011;18(1):67-76. doi:10.1016/j.chembiol.2010.11.009