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MedKoo Cat#: 535167 | Name: No. 407

Description:

WARNING: This product is for research use only, not for human or veterinary use.

No. 407 is a bioactive chemical.

Chemical Structure

No. 407
No. 407
CAS#66935-36-2

Theoretical Analysis

MedKoo Cat#: 535167

Name: No. 407

CAS#: 66935-36-2

Chemical Formula: C23H33N5O8S

Exact Mass: 539.2050

Molecular Weight: 539.60

Elemental Analysis: C, 51.20; H, 6.16; N, 12.98; O, 23.72; S, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
No. 407; No.-407; No.407
IUPAC/Chemical Name
Glycine, N-(N(sup 2)-((6,7-dimethoxy-2-naphthalenyl)sulfonyl)-L-arginyl)-N-(2-methoxyethyl)-
InChi Key
NWPBDBZSRAXKBY-SFHVURJKSA-N
InChi Code
InChI=1S/C23H33N5O8S/c1-34-10-9-28(14-21(29)30)22(31)18(5-4-8-26-23(24)25)27-37(32,33)17-7-6-15-12-19(35-2)20(36-3)13-16(15)11-17/h6-7,11-13,18,27H,4-5,8-10,14H2,1-3H3,(H,29,30)(H4,24,25,26)/t18-/m0/s1
SMILES Code
O=C(O)CN(C([C@H](CCCNC(N)=N)NS(=O)(C1=CC=C2C=C(OC)C(OC)=CC2=C1)=O)=O)CCOC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 539.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Retraction: The following College document has been withdrawn: ACOG Committee Opinion No. 407: Low Bone Mass (Osteopenia) and Fracture Risk (Obstet Gynecol 2008;111:1259–61). Obstet Gynecol. 2012 Oct;120(4):963. doi: 10.1097/AOG.0b013e3182723afe. PMID: 22996125. 2: Higashihara N, Shiraishi K, Miyata K, Oshima Y, Minobe Y, Yamasaki K. Subacute oral toxicity study of bisphenol F based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol. 2007 Dec;81(12):825-32. doi: 10.1007/s00204-007-0223-4. Epub 2007 Jul 13. PMID: 17628788. 3: Andrews P, Freyberger A, Hartmann E, Eiben R, Loof I, Schmidt U, Temerowski M, Folkerts A, Stahl B, Kayser M. Sensitive detection of the endocrine effects of the estrogen analogue ethinylestradiol using a modified enhanced subacute rat study protocol (OECD Test Guideline no. 407). Arch Toxicol. 2002 May;76(4):194-202. doi: 10.1007/s00204-002-0337-7. Epub 2002 Apr 4. PMID: 12029382. 4: Yang WJ, Yang CS, Huang CJ, Chen KS, Lin SF. Bostrycin, a novel coupling agent for protein immobilization and prevention of biomaterial-centered infection produced by Nigrospora sp. No. 407. Enzyme Microb Technol. 2012 May 10;50(6-7):287-92. doi: 10.1016/j.enzmictec.2012.02.002. Epub 2012 Feb 22. PMID: 22500894. 5: Shiraishi K, Miyata K, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K. Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407". Arch Toxicol. 2006 Jan;80(1):10-6. doi: 10.1007/s00204-005-0008-6. Epub 2005 Jul 30. PMID: 16059724. 6: Andrews P, Freyberger A, Hartmann E, Eiben R, Loof I, Schmidt U, Temerowski M, Becka M. Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine- mediated effects of the antiandrogenic drug flutamide. Arch Toxicol. 2001 Apr;75(2):65-73. doi: 10.1007/s002040100214. PMID: 11354908. 7: Zhuchkov SA, Kinzirsky AS, Koroleva IV, Vicharev YB. Clinical and Morphological Aspects in Assessing the Safety of OSPL-502 with Repeated Dose Administration. Open Access Maced J Med Sci. 2018 Sep 23;6(9):1581-1587. doi: 10.3889/oamjms.2018.398. PMID: 30337969; PMCID: PMC6182547. 8: Yamasaki K, Tago Y, Nagai K, Sawaki M, Noda S, Takatsuki M. Comparison of toxicity studies based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' and the research protocol of 'Pubertal Development and Thyroid Function in Immature Male Rats' with 6-n-propyl-2-thiouracil. Arch Toxicol. 2002 Sep;76(9):495-501. doi: 10.1007/s00204-002-0371-5. Epub 2002 Jun 25. PMID: 12242606. 9: Shin JH, Moon HJ, Kang IH, Kim TS, Kim IY, Park IS, Kim HS, Jeung EB, Han SY. Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch Toxicol. 2006 Dec;80(12):797-803. doi: 10.1007/s00204-006-0116-y. PMID: 16710696. 10: Shin JH, Moon HJ, Kim TS, Kang IH, Ki HY, Choi KS, Han SY. Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch Toxicol. 2006 Sep;80(9):547-54. doi: 10.1007/s00204-006-0080-6. Epub 2006 Feb 18. PMID: 16489464. 11: Yamasaki K, Sawaki M, Noda S, Imatanaka N, Takatsuki M. Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol. 2002 Mar;76(2):65-74. doi: 10.1007/s00204-001-0319-1. Epub 2002 Feb 6. PMID: 11914775. 12: Yamasaki K, Takeyoshi M, Noda S, Takatsuki M. Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'. Toxicology. 2002 Jul 1;176(1-2):101-12. doi: 10.1016/s0300-483x(02)00160-9. PMID: 12062934. 13: ACOG Committee Opinion No. 407: low bone mass (osteopenia) and fracture risk. Obstet Gynecol. 2008 May;111(5):1259-61. doi: 10.1097/AOG.0b013e31817578fe. Retraction in: Obstet Gynecol. 2012 Oct;120(4):963. PMID: 18448770. 14: Huang YH, Yang WJ, Cheng CY, Sung HM, Lin SF. Bostrycin production by agro- industrial residues and its potential for food processing. Food Sci Biotechnol. 2017 May 29;26(3):715-721. doi: 10.1007/s10068-017-0082-6. PMID: 30263596; PMCID: PMC6049593. 15: Oda K, Ohtsu K, Tamao Y, Kikumoto R, Hijikata A, Kinjo K, Okamoto S. Comparison of plasma levels and excretory routes between No. 189 and No. 407, potent thrombin inhibitors. Kobe J Med Sci. 1980 Mar;26(1):11-31. PMID: 7392547. 16: Maraini G, Williams SL, Sperduto RD, Ferris FL, Milton RC, Clemons TE, Rosmini F, Ferrigno L. Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract. Ann Ist Super Sanita. 2009;45(2):119-27. PMID: 19636163. 17: Miyata K, Shiraishi K, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K. Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol. 2006 Apr;80(4):181-6. doi: 10.1007/s00204-005-0030-8. PMID: 16187103. 18: Ma P, Wang S, Wang T, Wu J, Xing X, Zhang X. Effect of bifunctional acid on the porosity improvement of biomass-derived activated carbon for methylene blue adsorption. Environ Sci Pollut Res Int. 2019 Oct;26(29):30119-30129. doi: 10.1007/s11356-019-06177-9. Epub 2019 Aug 16. PMID: 31418149. 19: Zhang Y, Lin Y, Zhang J, Li L, Liu X, Wang T, Gao Z. Association between insomnia and type 2 diabetes mellitus in Han Chinese individuals in Shandong Province, China. Sleep Breath. 2019 Mar;23(1):349-354. doi: 10.1007/s11325-018-1687-6. Epub 2018 Jun 30. PMID: 29961182. 20: Kunimatsu T, Yamada T, Miyata K, Yabushita S, Seki T, Okuno Y, Matsuo M. Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide. Toxicology. 2004 Jul 15;200(1):77-89. doi: 10.1016/j.tox.2004.03.007. PMID: 15158566.