MedKoo Cat#: 462491 | Name: Z-YVAD-FMK
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities.

Chemical Structure

Z-YVAD-FMK
Z-YVAD-FMK
CAS#210344-97-1

Theoretical Analysis

MedKoo Cat#: 462491

Name: Z-YVAD-FMK

CAS#: 210344-97-1

Chemical Formula: C31H39FN4O9

Exact Mass: 630.2701

Molecular Weight: 630.67

Elemental Analysis: C, 59.04; H, 6.23; F, 3.01; N, 8.88; O, 22.83

Price and Availability

Size Price Availability Quantity
1mg USD 400.00 2 Weeks
5mg USD 790.00 2 Weeks
10mg USD 1,270.00 2 Weeks
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Related CAS #
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Synonym
Z-YVAD-FMK; Z YVAD FMK; Z YVAD-FMK; Z-YVAD FMK
IUPAC/Chemical Name
Z-Tyr-Val-Ala-Asp-FMK
InChi Key
MVPQJUFFTWWKBT-LBDWYMBGSA-N
InChi Code
InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24-,27-/m0/s1
SMILES Code
O=C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C)=O)=O)OCC2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 630.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li H, Nookala S, Re F. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol. 2007;178(8):5271-5276. doi:10.4049/jimmunol.178.8.5271 2: Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B. Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002;132(7):1812-1818. doi:10.1093/jn/132.7.1812 3: Equils O, Moffatt-Blue C, Ishikawa TO, Simmons CF, Ilievski V, Hirsch E. Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect Dis Obstet Gynecol. 2009;2009:749432. doi:10.1155/2009/749432 4: Künstle G, Leist M, Uhlig S, et al. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett. 1997;55(1):5-10. doi:10.1016/s0165-2478(96)02642-9