MedKoo Cat#: 462489 | Name: Bozitinib
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bozitinib is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.

Chemical Structure

Bozitinib
Bozitinib
CAS#1440964-89-5

Theoretical Analysis

MedKoo Cat#: 462489

Name: Bozitinib

CAS#: 1440964-89-5

Chemical Formula: C20H15F3N8

Exact Mass: 424.1372

Molecular Weight: 424.39

Elemental Analysis: C, 56.60; H, 3.56; F, 13.43; N, 26.40

Price and Availability

Size Price Availability Quantity
5mg USD 530.00 2 Weeks
10mg USD 840.00 2 Weeks
25mg USD 1,650.00 2 Weeks
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Synonym
Bozitinib; PLB-1001; PLB1001; PLB 1001; CBT-101; CBT101; CBT 101; Vebreltinib
IUPAC/Chemical Name
6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine
InChi Key
QHXLXUIZUCJRKV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15F3N8/c1-29-9-11-6-14(15(21)7-17(11)27-29)20(22,23)19-26-25-18-5-4-16(28-31(18)19)12-8-24-30(10-12)13-2-3-13/h4-10,13H,2-3H2,1H3
SMILES Code
CN1N=C2C=C(F)C(C(C3=NN=C4C=CC(C5=CN(C6CC6)N=C5)=NN43)(F)F)=CC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 424.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18. doi: 10.1016/j.cell.2018.09.038. Epub 2018 Oct 18. PMID: 30343896. 2: Wang QW, Sun LH, Zhang Y, Wang Z, Zhao Z, Wang ZL, Wang KY, Li GZ, Xu JB, Ren CY, Ma WP, Wang HJ, Li SW, Zhu YJ, Jiang T, Bao ZS. MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor- associated, macrophages-mediated immunosuppression in primary glioblastomas. J Immunother Cancer. 2021 Oct;9(10):e002451. doi: 10.1136/jitc-2021-002451. PMID: 34667077; PMCID: PMC8527154.