STAT3-IN-3 | CAS#2361304-26-7 | STAT3 inhibitor

MedKoo Cat#: 462485 | Name: STAT3-IN-3

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3).

Chemical Structure

STAT3-IN-3

CAS#2361304-26-7

Theoretical Analysis

MedKoo Cat#: 462485

Name: STAT3-IN-3

CAS#: 2361304-26-7

Chemical Formula: C27H26BrN3O6S

Exact Mass: 599.0726

Molecular Weight: 600.48

Elemental Analysis: C, 54.01; H, 4.36; Br, 13.31; N, 7.00; O, 15.99; S, 5.34

Price and Availability

Size	Price	Availability
5mg	USD 550.00	2 Weeks
10mg	USD 900.00	2 Weeks
25mg	USD 1,550.00	2 Weeks

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Related CAS #

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Synonym

STAT3-IN-3; STAT3 IN 3; STAT3 IN-3; STAT3-IN 3

IUPAC/Chemical Name

3-(4-(4-bromo-1,1-dioxidocinnamoyl)piperazine-1-carbonyl)-7-(diethylamino)-2H-chromen-2-one

InChi Key

LEVMMUZFAXTJOJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H26BrN3O6S/c1-3-29(4-2)18-9-8-17-14-20(27(34)37-22(17)15-18)25(32)30-10-12-31(13-11-30)26(33)24-16-19-21(28)6-5-7-23(19)38(24,35)36/h5-9,14-16H,3-4,10-13H2,1-2H3

SMILES Code

BrC1=C2C(S(C(C(N3CCN(C(C4=CC5=CC=C(N(CC)CC)C=C5OC4=O)=O)CC3)=O)=C2)(=O)=O)=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

STAT3-IN-3 induces apoptosis in breast cancer cells.

In vitro activity:

Pretreatment with STAT3-IN-3 significantly inhibited the upregulation of P-gp and Bcl-2 protein expression induced by the miRNA-221 mimic in Saos-2 cells; it also caused the Saos-2 cells to overcome DOX resistance induced by the miRNA-221 mimic. Reference: Biol Pharm Bull. 2021 Jun 1;44(6):861-868. https://pubmed.ncbi.nlm.nih.gov/33828027/

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	5.0	8.33

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 600.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Liu Y, Liu X, Yang S. MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells. Biol Pharm Bull. 2021 Jun 1;44(6):861-868. doi: 10.1248/bpb.b21-00163. Epub 2021 Apr 8. PMID: 33828027.

In vitro protocol:

In vivo protocol:

To be determined

1: Cai G, Yu W, Song D, et al. Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. Eur J Med Chem. 2019;174:236-251. doi:10.1016/j.ejmech.2019.04.024