MedKoo Cat#: 574564 | Name: AR-C 102222

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-C 102222 is an inducible nitric oxide synthase (iNOS) inhibitor selective for iNOS over eNOS. AR-C 102222 exhibits antinociceptive and anti-inflammatory activity in rodent pain models.

Chemical Structure

AR-C 102222
CAS# 1781934-50-6

Theoretical Analysis

MedKoo Cat#: 574564

Name: AR-C 102222

CAS#: 1781934-50-6

Chemical Formula: C19H17ClF2N6O

Exact Mass: 418.1120

Molecular Weight: 418.83

Elemental Analysis: C, 54.49; H, 4.09; Cl, 8.46; F, 9.07; N, 20.07; O, 3.82

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Synonym
AR-C 102222
IUPAC/Chemical Name
5-[(4'-amino-5',8'-difluorospiro[piperidine-4,2'(1'h)-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride
InChi Key
FJFMOBYDHGJDGV-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16F2N6O.ClH/c20-13-3-4-14(21)16-15(13)17(23)26-19(25-16)5-7-27(8-6-19)18(28)11-1-2-12(9-22)24-10-11;/h1-4,10,25H,5-8H2,(H2,23,26);1H
SMILES Code
N#CC1=NC=C(C(N2CCC3(NC4=C(C(F)=CC=C4F)C(N)=N3)CC2)=O)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 418.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL