Nibentan | CAS#157832-56-9

MedKoo Cat#: 535138 | Name: Nibentan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nibentan is a bioactive chemical.

Chemical Structure

Nibentan

CAS#157832-56-9

Theoretical Analysis

MedKoo Cat#: 535138

Name: Nibentan

CAS#: 157832-56-9

Chemical Formula: C22H30ClN3O3

Exact Mass: 419.1976

Molecular Weight: 419.95

Elemental Analysis: C, 62.92; H, 7.20; Cl, 8.44; N, 10.01; O, 11.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Nibentan

IUPAC/Chemical Name

Benzamide, N-(5-(diethylamino)-1-phenylpentyl)-4-nitro-, monohydrochloride

InChi Key

CHCBAYRWJULIDW-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H29N3O3.ClH/c1-3-24(4-2)17-9-8-12-21(18-10-6-5-7-11-18)23-22(26)19-13-15-20(16-14-19)25(27)28;/h5-7,10-11,13-16,21H,3-4,8-9,12,17H2,1-2H3,(H,23,26);1H

SMILES Code

O=C(NC(C1=CC=CC=C1)CCCCN(CC)CC)C2=CC=C([N+]([O-])=O)C=C2.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 419.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chapurnykh AV, Solov'ev OV, Zavalin AV, Pavlov EG, Efremov DN. [Nibentan in arresting acute atrial fibrillation: risk or benefit?]. Ter Arkh. 2008;80(1):41-5. Russian. PMID: 18326226. 2: Popova EP, Lyskovtsev VV, Kaverina NV. [Effect of the class III antiarrhythmic drug nibentan in vagotonic atrial fibrillation]. Eksp Klin Farmakol. 2006 Jan-Feb;69(1):24-7. Russian. PMID: 16579055. 3: Glukhov AV, Reznik AV, Kovalenko NV, Egorov IuV, Rozenshtraukh LV. [Effect of nibentan on dispersion of repolarization of ventricular myocardium in the rabbit]. Kardiologiia. 2008;48(7):40-7. Russian. PMID: 18789025. 4: Kotliarov AA, Kurkina NV, Smirnova LE, Balykova LA. Issledovanie vliianiia meksidola, émoksipina i dimefosfona na élektrofiziologicheskie éffekty nibentana [Effect of mexidol, emoxypine, and dimephosphon on electrophysiological effects of nibentan]. Eksp Klin Farmakol. 2002 Mar-Apr;65(2):27-30. Russian. PMID: 12109287. 5: Fedorov VV, Sharifov OF, Beloshapko GG, Yushmanova AV, Rosenshtraukh LV. Effects of a new class III antiarrhythmic drug nibentan in a canine model of vagally mediated atrial fibrillation. J Cardiovasc Pharmacol. 2000 Jul;36(1):77-89. doi: 10.1097/00005344-200007000-00011. PMID: 10892664. 6: Giliarov MIu, Novikova NA, Sulimov VA, Suchkova SA, Syrkin AL. [Comparison of the efficacy and safety of electrical cardioversion and pharmacological cardioversion with nibentan in patients with persisting atrial fibrillation and flutter]. Vestn Ross Akad Med Nauk. 2007;(5):22-6. Russian. PMID: 17601037. 7: Bregvadze IN, Maĭkov EB, Bil'dinov OA, Kratskina TL, Klimenko IuL, Smirnova MIu, Sokolov SF, Golitsyn SP, Rozenshtraukh LV, Chazov EI. [The efficacy and safety of nibentan for pharmacological cardioversion in patients with persistent atrial fibrillation and flutter: the role of dose limitation and magnesium sulfate administration]. Kardiologiia. 2007;47(3):48-55. Russian. PMID: 17495849. 8: Kaverina NV, Lyskovtsev VV, Popova EP. [Comparative study of the electrophysiological properties of class iii medicinals (cardiocyclide, nibentan, sotalol) and evaluation of their efficacy in atrial fibrillation produced by auricular and vagal stimulation]. Eksp Klin Farmakol. 2007 Jan- Feb;70(1):11-6. Russian. PMID: 17402585. 9: Fedorov VV, Vinogradova TM, Bogdanov KIu, Rozenshtraukh LV. Kholinoliticheskaia aktivnost' novogo antiaritmicheskogo preparata "Nibentan" [The cholinolytic activity of the new anti-arrhythmia preparation Nibentan]. Ross Fiziol Zh Im I M Sechenova. 1999 Mar;85(3):383-94. Russian. PMID: 10494589. 10: Kaverina NV, Lyskovtsev VV, Popova EP. Sravnitel'noe izuchenie élektrofiziologicheskikh mekhanizmov antiaritmicheskikh preparatov III klassa kardiotsiklida, nibentana i sotalona na fone éksperimental'nogo infarkta miokarda i simpaticheskoĭ stimuliatsii [Comparative study of electrophysiological mechanisms of anti-arrhythmia III class agents, cardiocyclide, nibentan, and sotalol during experimental myocardial infarction and sympathetic stimulation]. Eksp Klin Farmakol. 2003 Jan-Feb;66(1):27-33. Russian. PMID: 12683077. 11: Anyukhovsky EP, Sosunov EA, Rosen MR. Electrophysiologic effects of nibentan (HE-11) on canine cardiac tissue. J Pharmacol Exp Ther. 1997 Mar;280(3):1137-46. PMID: 9067296. 12: Turilova AI, Katsitadze NSh, Kaverina NV. Deĭstvie novykh antiaritmicheskikh preparatov III klassa--kardiotsiklida i nibentana na fone aktivatsii beta- adrenoretseptorov serdtsa [The effect of novel class III anti-arrhythmia agents cardiocyclide and nibentan during activation of cardiac beta-adrenoreceptors]. Eksp Klin Farmakol. 2002 Sep-Oct;65(5):29-30. Russian. PMID: 12596510. 13: Shubik IuV, Medvedev MM, Rivin AE. [Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation]. Kardiologiia. 2005;45(3):19-23. Russian. PMID: 15821703. 14: Latfullin IA, Gaifullina RF, Dzhordzhikiya RK, Nigmatullina RR. Myocardial contractility after in vitro treatment with class III antiarrhythmic drug Nibentan. Bull Exp Biol Med. 2006 Jan;141(1):81-3. doi: 10.1007/s10517-006-0099-y. PMID: 16929971. 15: Vititnova MB, Kryzhanovskiĭ SA, Kaverina NV. Sravnitel'noe izuchenie antiaritmicheskoĭ aktivnosti kardiotsiklida i nibentana v usloviiakh gipersimpatotonii i ostroĭ ishemii miokarda [Comparative study of the anti- arrhythmic activity of cardiocyclide and nibentan in hypersympathotonia and acute myocardial ischemia]. Eksp Klin Farmakol. 2002 Mar-Apr;65(2):24-6. Russian. PMID: 12109286. 16: Afanas'ev SA, Lukavskaya IA, Ugdyzhekova DS, Popov SV, Antonchenko IV, Abubakirova GO, Medvedev MA. Effect of class III antiarrhythmic preparation nibentan on extrasystolic and post-extrasystolic contraction of rat papillary muscle. Bull Exp Biol Med. 2002 Jul;134(1):15-7. doi: 10.1023/a:1020636000669. PMID: 12459857. 17: Kotliarov AA, Napalkova SM, Babin VV, Skachilova SIa. Vliianie proizvodnogo nibentana LKhT53-91 na élektrofiziologicheskie parametry serdtsa [Effect of a nibentan derivative LKhT53-91 on the heart electrophysiological parameters]. Eksp Klin Farmakol. 2002 May-Jun;65(3):10-2. Russian. PMID: 12227085. 18: Davydova NK, Sizova OS, Vinogradova SM, L'vov AI, Glushkov RG, Yuzhakov SD, Mashkovskiy MD. Synthesis and antifibrillatory activity of nibentan and its analogues. Eur J Med Chem. 2000 Feb;35(2):205-15. doi: 10.1016/s0223-5234(00)00116-1. PMID: 10758282. 19: Glushkov RG, Golitsyn SP, Dorodnikova EV, Maĭkov EB, Mashkovskiĭ MD, Merkulova IN, Rozenshtraukh LV, Ruda MIa, Skachilova SIa, Chazov EI, Iuzhakov SD. Pervyĭ original'nyĭ otechestvennyĭ antiaritmik III klassa nibentan [The first original Russian class-III antiarrhythmic nibentan]. Vestn Ross Akad Med Nauk. 1998;(11):38-41. Russian. PMID: 9889704. 20: Ugdyzhekova DS, Afanas'ev SA, Lukavskaia IA, Popov SV. [Cardiac effects of the class III antiarrhythmic drugs amiodarone and nibentan]. Fiziol Cheloveka. 2005 Jul-Aug;31(4):113-8. Russian. PMID: 16122045.