MedKoo Cat#: 462456 | Name: BLM-IN-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor.

Chemical Structure

BLM-IN-1
BLM-IN-1
CAS#2056014-40-3

Theoretical Analysis

MedKoo Cat#: 462456

Name: BLM-IN-1

CAS#: 2056014-40-3

Chemical Formula: C28H35FN4O

Exact Mass: 462.2795

Molecular Weight: 462.61

Elemental Analysis: C, 72.70; H, 7.63; F, 4.11; N, 12.11; O, 3.46

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,250.00 2 Weeks
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Synonym
BLM-IN-1; BLM IN 1; BLM IN-1;BLM-IN 1
IUPAC/Chemical Name
(E)-6-((3-(diethylamino)propyl)amino)-7-fluoro-3-(4-isopropylbenzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
InChi Key
GZSNGNPLURZQGM-CJLVFECKSA-N
InChi Code
InChI=1S/C28H35FN4O/c1-5-32(6-2)14-7-13-30-26-18-25-23(17-24(26)29)28(34)33-15-12-22(27(33)31-25)16-20-8-10-21(11-9-20)19(3)4/h8-11,16-19,30H,5-7,12-15H2,1-4H3/b22-16+
SMILES Code
FC1=CC2=C(N=C(/C(CC3)=C/C4=CC=C(C(C)C)C=C4)N3C2=O)C=C1NCCCN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 462.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yin QK, Wang CX, Wang YQ, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019;62(6):3147-3162. doi:10.1021/acs.jmedchem.9b00083