Synonym
(R)-Duloxetine Hydrochloride
IUPAC/Chemical Name
(R)-N-Methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine Hydrochloride
InChi Key
BFFSMCNJSOPUAY-UNTBIKODSA-N
InChi Code
InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m1./s1
SMILES Code
CNCC[C@@H](OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
333.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cui R, Wang Z, Li L, Liu L, Li Z, Liu X, Chen T, Rauf A, Kang X, Guo Y. Bionic nanopore recognition receptors for single-molecule enantioselectivity studies of chiral drugs. Anal Chim Acta. 2024 Aug 22;1318:342960. doi: 10.1016/j.aca.2024.342960. Epub 2024 Jul 10. PMID: 39067929.
2: Wang CF, Russell G, Wang SY, Strichartz GR, Wang GK. R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. Anesth Analg. 2016 Mar;122(3):719-729. doi: 10.1213/ANE.0000000000001086. PMID: 26646348.
3: Sánchez-López E, Montealegre C, Marina ML, Crego AL. Development of chiral methodologies by capillary electrophoresis with ultraviolet and mass spectrometry detection for duloxetine analysis in pharmaceutical formulations. J Chromatogr A. 2014 Oct 10;1363:356-62. doi: 10.1016/j.chroma.2014.07.038. Epub 2014 Jul 18. PMID: 25085818.
4: Sánchez-López E, Salgado A, Crego AL, Marina ML. Investigation on the enantioseparation of duloxetine by capillary electrophoresis, NMR, and mass spectrometry. Electrophoresis. 2014 Oct;35(19):2842-7. doi: 10.1002/elps.201300656. Epub 2014 May 19. PMID: 24659027.
5: Träff A, Lihammar R, Bäckvall JE. A chemoenzymatic dynamic kinetic resolution approach to enantiomerically pure (R)- and (S)-duloxetine. J Org Chem. 2011 May 20;76(10):3917-21. doi: 10.1021/jo2003665. Epub 2011 Apr 18. PMID: 21449618.
