Synonym
2'-Deoxyguanosine; Guanine deoxyriboside; NSC 22837; NSC-22837; NSC-22837
IUPAC/Chemical Name
2-amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChi Key
YKBGVTZYEHREMT-KVQBGUIXSA-N
InChi Code
InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
SMILES Code
NC1=NC(C(N=CN2[C@]3([H])O[C@H](CO)[C@@H](O)C3)=C2N1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
267.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ross, D.D., Akman, S.A., Schrecker, A.W., et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 41(11 Pt 1), 4493-4498 (1981).
2: Mitchell, B.S., Mejias, E., Daddona, P.E., et al. Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cells. Proc. Natl. Acad. Sci. USA 75(10), 5011-5014 (1978).
3: Brulfert, A., Clain, E., and Deysson, G. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia 30(9), 1010-1011 (1974).
4: Scholar, E.M. Effect of deoxypurine and deoxypyrimidine compounds on the vascular responsiveness of bovine coronary and lingual arteries. J. Pharm. Pharmacol. 32(10), 726 (1980).
