SRX3212 is a Novel BRD4/PI3Kα inhibitor, displaying an IC50 of 3.7 nM toward BRD4BD1 and 32 nM toward BRD4BD2, and therefore was~65-fold more potent inhibitor of BRD4BD1 and~48-fold more potent inhibitor of BRD4BD2 than SF2523 (GLXC-10641), retaining its high inhibitory activity for PI3Kα (IC50: 22 nM).
MedKoo Cat#: 535112
Name: SRX3212
CAS#: 2735720-80-4
Chemical Formula: C26H23N3O6S
Exact Mass: 505.1308
Molecular Weight: 505.55
Elemental Analysis: C, 61.77; H, 4.59; N, 8.31; O, 18.99; S, 6.34
The following data is based on the product molecular weight 505.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
