Ro 11-2933 | CAS#98600-65-8 | Tiapamil Analog

MedKoo Cat#: 535078 | Name: Ro 11-2933

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 11-2933 is an analog of tiapamil.

Chemical Structure

Ro 11-2933

CAS#98600-65-8

Theoretical Analysis

MedKoo Cat#: 535078

Name: Ro 11-2933

CAS#: 98600-65-8

Chemical Formula: C28H35NO2S2

Exact Mass: 481.2109

Molecular Weight: 481.71

Elemental Analysis: C, 69.82; H, 7.32; N, 2.91; O, 6.64; S, 13.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ro 11-2933

IUPAC/Chemical Name

1,3-Dithiane-2-propanamine, N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-2-(2-naphthalenyl)-

InChi Key

YEXYNWAZYPPKQD-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H35NO2S2/c1-29(17-14-22-10-13-26(30-2)27(20-22)31-3)16-6-15-28(32-18-7-19-33-28)25-12-11-23-8-4-5-9-24(23)21-25/h4-5,8-13,20-21H,6-7,14-19H2,1-3H3

SMILES Code

CN(CCC1=CC=C(OC)C(OC)=C1)CCCC2(C3=CC=C4C=CC=CC4=C3)SCCCS2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

1: Abderrabi M, Marchal S, Merlin JL. Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators. Anticancer Drugs. 1996 Jun;7(4):430-6. doi: 10.1097/00001813-199606000-00009. PMID: 8826612. 2: Mazzoni A. In vitro reversal of doxorubicin resistance by the tiapamil analog RO 11-2933 in human ovarian cancer cells. Tumori. 1990 Feb 28;76(1):69-72. PMID: 2321277. 3: Mazzoni A, Canti G. Reversal of doxorubicin and cisplatin resistance in vivo in murine leukemias by the calcium antagonist RO 11-2933. Sel Cancer Ther. 1990 Winter;6(4):167-76. doi: 10.1089/sct.1990.6.167. PMID: 2094936. 4: Alaoui-Jamali MA, Schecter RL, Rustum YM, Centurioni MG, Lehnert S, Batist G. In vivo reversal of doxorubicin resistance by a new tiapamil analog Ro11-2933. J Pharmacol Exp Ther. 1993 Mar;264(3):1299-304. PMID: 8450465. 5: Mazzoni A, Trave F, Canti G, Franco P. Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells. Anticancer Res. 1989 Mar-Apr;9(2):367-71. PMID: 2751261. 6: Eliason JF, Sawada R, Tsukaguchi T, Kobayashi K, Ichihara S, Konishi C, Horii I, Kuruma I, Ramuz H. The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo. Eur J Cancer. 1995 Dec;31A(13-14):2354-61. doi: 10.1016/0959-8049(95)00418-1. PMID: 8652269. 7: Kyle DE, Milhous WK, Rossan RN. Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. Am J Trop Med Hyg. 1993 Jan;48(1):126-33. doi: 10.4269/ajtmh.1993.48.126. PMID: 8427381. 8: Plumb JA, Wishart GC, Setanoians A, Morrison JG, Hamilton T, Bicknell SR, Kaye SB. Identification of a multidrug resistance modulator with clinical potential by analysis of synergistic activity in vitro, toxicity in vivo and growth delay in a solid human tumour xenograft. Biochem Pharmacol. 1994 Jan 20;47(2):257-66. doi: 10.1016/0006-2952(94)90015-9. PMID: 8304970. 9: Schuurhuis GJ, Broxterman HJ, Cervantes A, van Heijningen TH, de Lange JH, Baak JP, Pinedo HM, Lankelma J. Quantitative determination of factors contributing to doxorubicin resistance in multidrug-resistant cells. J Natl Cancer Inst. 1989 Dec 20;81(24):1887-92. doi: 10.1093/jnci/81.24.1887. PMID: 2574239. 10: Campain JA, Padmanabhan R, Hwang J, Gottesman MM, Pastan I. Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. J Cell Physiol. 1993 May;155(2):414-25. doi: 10.1002/jcp.1041550224. PMID: 8097746. 11: Kyle DE, Oduola AM, Martin SK, Milhous WK. Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro. Trans R Soc Trop Med Hyg. 1990 Jul- Aug;84(4):474-8. doi: 10.1016/0035-9203(90)90004-x. PMID: 2091331. 12: Broxterman HJ, Kuiper CM, Schuurhuis GJ, van der Hoeven JJ, Pinedo HM, Lankelma J. Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: role of protein binding. Cancer Lett. 1987 Apr;35(1):87-95. doi: 10.1016/0304-3835(87)90060-7. PMID: 3471315. 13: Spoelstra EC, Dekker H, Schuurhuis GJ, Broxterman HJ, Lankelma J. P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport. Biochem Pharmacol. 1991 Feb 1;41(3):349-59. doi: 10.1016/0006-2952(91)90531-9. PMID: 1671638. 14: Radel S, Bankusli I, Mayhew E, Rustum YM. The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin- resistant and -sensitive leukemia in vitro and in vivo. Cancer Chemother Pharmacol. 1988;21(1):25-30. doi: 10.1007/BF00262733. PMID: 3342462. 15: Horio M, Lovelace E, Pastan I, Gottesman MM. Agents which reverse multidrug- resistance are inhibitors of [3H]vinblastine transport by isolated vesicles. Biochim Biophys Acta. 1991 Jan 9;1061(1):106-10. doi: 10.1016/0005-2736(91)90274-c. PMID: 1671642. 16: Wigler PW, Patterson FK. Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Biochim Biophys Acta. 1994 Jan 3;1189(1):1-6. doi: 10.1016/0005-2736(94)90272-0. PMID: 7905747. 17: Chong AS, Markham PN, Gebel HM, Bines SD, Coon JS. Diverse multidrug- resistance-modification agents inhibit cytolytic activity of natural killer cells. Cancer Immunol Immunother. 1993;36(2):133-9. doi: 10.1007/BF01754414. PMID: 8093856. 18: Watt G, Long GW, Grogl M, Martin SK. Reversal of drug-resistant falciparum malaria by calcium antagonists: potential for host cell toxicity. Trans R Soc Trop Med Hyg. 1990 Mar-Apr;84(2):187-90. doi: 10.1016/0035-9203(90)90248-d. PMID: 1975136. 19: Yin MB, Bankusli I, Rustum YM. Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice. Cancer Res. 1989 Sep 1;49(17):4729-33. PMID: 2758408.

Instruction

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Preparing Stock Solutions

The following data is based on the product molecular weight 481.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.