MedKoo Cat#: 462400 | Name: TAS4464 hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAS4464 hydrochloride is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE).

Chemical Structure

TAS4464 hydrochloride
TAS4464 hydrochloride
CAS#1848959-11-4

Theoretical Analysis

MedKoo Cat#: 462400

Name: TAS4464 hydrochloride

CAS#: 1848959-11-4

Chemical Formula: C21H24ClFN6O6S

Exact Mass: 542.1151

Molecular Weight: 542.97

Elemental Analysis: C, 46.45; H, 4.46; Cl, 6.53; F, 3.50; N, 15.48; O, 17.68; S, 5.90

Price and Availability

Size Price Availability Quantity
5mg USD 530.00 2 Weeks
10mg USD 940.00 2 Weeks
50mg USD 2,450.00 2 Weeks
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Synonym
TAS4464 hydrochloride; TAS 4464 hydrochloride; TAS-4464 hydrochloride
IUPAC/Chemical Name
A name could not be generated for this structure.
InChi Key
CDCFJYCKNAWPTL-WVAMHNCPSA-N
InChi Code
InChI=1S/C21H23FN6O6S.ClH/c1-2-33-14-5-3-4-13(22)12(14)7-6-11-9-28(20-16(11)19(23)25-10-26-20)21-18(30)17(29)15(34-21)8-27-35(24,31)32;/h3-5,9-10,15,17-18,21,27,29-30H,2,8H2,1H3,(H2,23,25,26)(H2,24,31,32);1H/t15-,17-,18-,21-;/m1./s1
SMILES Code
NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[C@@H]4O[C@H](CNS(=O)(N)=O)[C@@H](O)[C@H]4O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 542.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yoshimura C, Muraoka H, Ochiiwa H, et al. TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models. Mol Cancer Ther. 2019;18(7):1205-1216. doi:10.1158/1535-7163.MCT-18-0644