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MedKoo Cat#: 535046 | Name: Tiotidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiotidine is a histamine H2 receptor agonist.

Chemical Structure

Tiotidine
CAS#69014-14-8

Theoretical Analysis

MedKoo Cat#: 535046

Name: Tiotidine

CAS#: 69014-14-8

Chemical Formula: C10H16N8S2

Exact Mass: 312.0939

Molecular Weight: 312.41

Elemental Analysis: C, 38.45; H, 5.16; N, 35.87; S, 20.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tiotidine
IUPAC/Chemical Name
Guanidine, N''-cyano-N-(2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-
InChi Key
YDDXVAXDYKBWDX-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)
SMILES Code
CN/C(NCCSCC1=CSC(/N=C(N)\N)=N1)=N\C#N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Black JW, Leff P, Shankley NP. Pharmacological analysis of the pentagastrin- tiotidine interaction in the mouse isolated stomach. Br J Pharmacol. 1985 Nov;86(3):589-99. doi: 10.1111/j.1476-5381.1985.tb08935.x. PMID: 2866003; PMCID: PMC1916726. 2: Monczor F, Fernandez N, Legnazzi BL, Riveiro ME, Baldi A, Shayo C, Davio C. Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64(2):512-20. doi: 10.1124/mol.64.2.512. PMID: 12869657. 3: Batzri S, Harmon JW. Is [3H]-tiotidine a specific ligand for the H2-receptor? Pharmacology. 1986;32(5):241-7. doi: 10.1159/000138176. PMID: 2872690. 4: Zawilska JB, Woldan-Tambor A, Nowak JZ. Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. J Neurochem. 2002 Jun;81(5):935-46. doi: 10.1046/j.1471-4159.2002.00870.x. PMID: 12065605. 5: Dobson P, Yellin TO. A radioimmunoassay for the histamine H2-antagonist, tiotidine. Agents Actions. 1984 Oct;15(3-4):162-6. doi: 10.1007/BF01972343. PMID: 6151804. 6: Trzeciakowski JP, Levi R. The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214(3):629-34. PMID: 6105207. 7: Barker LA. Histamine H1- and muscarinic receptor antagonist activity of cimetidine and tiotidine in the guinea pig isolated ileum. Agents Actions. 1981 Dec;11(6-7):699-705. doi: 10.1007/BF01978792. PMID: 6122357. 8: Richardson CT, Feldman M, Brater C, Welborn J. Tiotidine, a new long-acting histamine H2-receptor antagonist: comparison with cimetidine. Gastroenterology. 1981 Feb;80(2):301-6. PMID: 6108895. 9: Valenzuela JE, Strecker RB, Douglas AP. Tiotidine, a new H2-receptor antagonist, is a potent inhibitor of nocturnal acid secretion in duodenal ulcer patients. Dig Dis Sci. 1981 May;26(5):433-7. doi: 10.1007/BF01313586. PMID: 6113920. 10: Kaojarern S, Feldman M, Richardson CT, Brater DC. Tiotidine and cimetidine-- kinetics and dynamics. Clin Pharmacol Ther. 1981 Feb;29(2):198-202. doi: 10.1038/clpt.1981.31. PMID: 6109588. 11: Cavanagh RL, Usakewicz JJ, Buyniski JP. A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine. J Pharmacol Exp Ther. 1983 Jan;224(1):171-9. PMID: 6129316. 12: Ridzwan BH, Waton NG, Jais AM. Anti-acid secretion activity of drugs cimetidine, ranitidine, tiotidine D 15,144 in dogs fixed with gastric fistulae. Gen Pharmacol. 1989;20(2):133-6. doi: 10.1016/0306-3623(89)90004-9. PMID: 2565846. 13: Foreman JC, Norris DB, Rising TJ, Webber SE. The binding of [3H]-tiotidine to homogenates of guinea-pig lung parenchyma. Br J Pharmacol. 1985 Oct;86(2):475-82. doi: 10.1111/j.1476-5381.1985.tb08917.x. PMID: 2864974; PMCID: PMC1916699. 14: Hoffman JM, Pietruszkiewicz AM, Habecker CN, Phillips BT, Bolhofer WA, Cragoe EJ Jr, Torchiana ML, Lumma WC Jr, Baldwin JJ. Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. J Med Chem. 1983 Feb;26(2):140-4. doi: 10.1021/jm00356a005. PMID: 6131129. 15: Zawilska JB, Zalewska-Kaszubska J, Przybysz M, Nowak JZ. Characterization of histamine H(2)-like receptors in duck cerebral cortical membranes by [(3)H]tiotidine binding. Neurosci Lett. 2002 Feb 22;319(3):149-52. doi: 10.1016/s0304-3940(01)02574-5. PMID: 11834315. 16: Wolf C, Schulze FR, Buschauer A, Schunack W. Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures. Eur J Pharm Sci. 1998 Jul;6(3):187-96. doi: 10.1016/s0928-0987(97)10017-3. PMID: 9795053. 17: Hattori Y, Endou M, Gando S, Kanno M. Identification and characterization of histamine H1- and H2-receptors in guinea-pig left atrial membranes by [3H]-mepyramine and [3H]-tiotidine binding. Br J Pharmacol. 1991 Jun;103(2):1573-9. doi: 10.1111/j.1476-5381.1991.tb09829.x. PMID: 1909203; PMCID: PMC1908349. 18: Humphray JM, Daly MJ, Stables R. Pharmacological interactions between ranitidine, cimetidine, metiamide and tiotidine at histamine H2-receptor sites in guinea-pig atria. Agents Actions. 1982 Apr;12(1-2):138-41. doi: 10.1007/BF01965124. PMID: 6282071. 19: Gajtkowski GA, Norris DB, Rising TJ, Wood TP. Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex. Nature. 1983 Jul 7-13;304(5921):65-7. doi: 10.1038/304065a0. PMID: 6135157. 20: Smith IR, Leigh BK, Mylek ME. 3H-tiotidine binding to guinea-pig cortical and striatal membranes. Agents Actions. 1986 Nov;19(3-4):169-73. doi: 10.1007/BF01966202. PMID: 3825739.

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