IDN-7314 | CAS#254750-11-3

MedKoo Cat#: 535045 | Name: IDN-7314

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDN-7314 is a bioactive chemical.

Chemical Structure

IDN-7314

CAS#254750-11-3

Theoretical Analysis

MedKoo Cat#: 535045

Name: IDN-7314

CAS#: 254750-11-3

Chemical Formula: C22H16F6N2O7

Exact Mass: 534.0862

Molecular Weight: 534.37

Elemental Analysis: C, 49.45; H, 3.02; F, 21.33; N, 5.24; O, 20.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IDN-7314; IDN 7314; IDN7314

IUPAC/Chemical Name

N-(2,6-Difluorophenyl)-2-oxoglycyl-N-((1S)-1-(carboxymethyl)-2-oxo-3- (2,3,5,6-tetrafluorophenoxy)propyl)-L-alaninamide

InChi Key

FEWNIOCTWJRBDB-XPTSAGLGSA-N

InChi Code

InChI=1S/C22H16F6N2O7/c1-9(22(36)29-16(33)7-31)30(20-10(23)3-2-4-11(20)24)14(6-17(34)35)15(32)8-37-21-18(27)12(25)5-13(26)19(21)28/h2-5,7,9,14H,6,8H2,1H3,(H,34,35)(H,29,33,36)/t9-,14-/m0/s1

SMILES Code

C[C@@H](C(NC(C=O)=O)=O)N(C1=C(F)C=CC=C1F)[C@@H](CC(O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 534.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C. Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis. Gut. 2019 Aug;68(8):1477-1492. doi: 10.1136/gutjnl-2018-316670. Epub 2019 Mar 14. PMID: 30872395. 2: Kopec AK, Spada AP, Contreras PC, Mackman N, Luyendyk JP. Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo. Toxicol Sci. 2018 Apr 1;162(2):396-405. doi: 10.1093/toxsci/kfx268. PMID: 29228388; PMCID: PMC5888917. 3: Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicol Sci. 2004 Jan;77(1):172-82. doi: 10.1093/toxsci/kfh011. Epub 2003 Nov 4. PMID: 14600277. 4: Cubero FJ, Peng J, Liao L, Su H, Zhao G, Zoubek ME, Macías-Rodríguez R, Ruiz- Margain A, Reißing J, Zimmermann HW, Gassler N, Luedde T, Liedtke C, Hatting M, Trautwein C. Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. J Hepatol. 2018 Dec;69(6):1326-1334. doi: 10.1016/j.jhep.2018.08.015. Epub 2018 Aug 23. PMID: 30144553. 5: Oliver Metzig M, Fuchs D, Tagscherer KE, Gröne HJ, Schirmacher P, Roth W. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF- α-dependent necroptosis driven by RIP1 kinase and NF-κB. Oncogene. 2016 Jun 30;35(26):3399-409. doi: 10.1038/onc.2015.398. Epub 2015 Nov 2. PMID: 26522725. 6: Gujral JS, Farhood A, Jaeschke H. Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats. Toxicol Appl Pharmacol. 2003 Jul 1;190(1):37-46. doi: 10.1016/s0041-008x(03)00154-6. PMID: 12831781.