MedKoo Cat#: 462340 | Name: SGC-AAK1-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor. It also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1.

Chemical Structure

SGC-AAK1-1
CAS#2247894-32-0

Theoretical Analysis

MedKoo Cat#: 462340

Name: SGC-AAK1-1

CAS#: 2247894-32-0

Chemical Formula: C21H25N5O3S

Exact Mass: 427.1678

Molecular Weight: 427.52

Elemental Analysis: C, 59.00; H, 5.89; N, 16.38; O, 11.23; S, 7.50

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,350.00 2 Weeks
200mg USD 2,150.00 2 Weeks
500mg USD 3,450.00 2 Weeks
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Synonym
SGC-AAK1-1; SGC AAK1-1; SGC-AAK1 1; SGC AAK1 1
IUPAC/Chemical Name
N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
InChi Key
UCBIQZUJJSVQHL-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,24,27)
SMILES Code
O=C(C1CC1)NC2=NNC3=C2C=CC(C4=CC=CC(NS(=O)(N(CC)CC)=O)=C4)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 427.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Agajanian MJ, Walker MP, Axtman AD, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26(1):79-93.e8. doi:10.1016/j.celrep.2018.12.023