ML00253764 is a non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 0.32, 0.81 and 2.12 μM for MC4, MC3 and MC5 receptors respectively). ML00253764 decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor. ML00253764 increases food intake and reduces loss of lean body mass in tumor bearing mice. It is also a brain penetrant.
MedKoo Cat#: 462337
Name: ML00253764 free base
CAS#: 681847-92-7 (free base)
Chemical Formula: C18H19BrClFN2O
Exact Mass: 412.0353
Molecular Weight: 413.72
Elemental Analysis: C, 52.26; H, 4.63; Br, 19.31; Cl, 8.57; F, 4.59; N, 6.77; O, 3.87
The following data is based on the product molecular weight 413.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
