MedKoo Cat#: 462335 | Name: Mutant IDH1-IN-4
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mutant IDH1-IN-4 is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.

Chemical Structure

Mutant IDH1-IN-4
Mutant IDH1-IN-4
CAS#1416270-18-2

Theoretical Analysis

MedKoo Cat#: 462335

Name: Mutant IDH1-IN-4

CAS#: 1416270-18-2

Chemical Formula: C25H34N4O3

Exact Mass: 438.2631

Molecular Weight: 438.57

Elemental Analysis: C, 68.47; H, 7.81; N, 12.78; O, 10.94

Price and Availability

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5mg USD 1,030.00 2 Weeks
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Related CAS #
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Synonym
Mutant IDH1 IN 4; Mutant IDH1 IN-4; Mutant IDH1-IN 4; Mutant IDH1-IN-4
IUPAC/Chemical Name
(R)-8-cyclopropyl-6-(3-cyclopropyl-4-(3-methoxypropanoyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile
InChi Key
GNDMXEAGAZOBEM-NRFANRHFSA-N
InChi Code
InChI=1S/C25H34N4O3/c1-25(2)12-18-19(13-26)24(27-23(17-6-7-17)20(18)15-32-25)28-9-10-29(22(30)8-11-31-3)21(14-28)16-4-5-16/h16-17,21H,4-12,14-15H2,1-3H3/t21-/m0/s1
SMILES Code
N#CC1=C(N2C[C@@H](C3CC3)N(C(CCOC)=O)CC2)N=C(C4CC4)C5=C1CC(C)(C)OC5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 438.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: US20170210749A1.