L 691121 | CAS#136075-61-1

MedKoo Cat#: 559147 | Name: L 691121

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 691121 is a bioactive chemical.

Chemical Structure

L 691121

CAS#136075-61-1

Theoretical Analysis

MedKoo Cat#: 559147

Name: L 691121

CAS#: 136075-61-1

Chemical Formula: C22H24N4O5S

Exact Mass: 456.1467

Molecular Weight: 456.52

Elemental Analysis: C, 57.88; H, 5.30; N, 12.27; O, 17.52; S, 7.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 691121; L-691121; L691121

IUPAC/Chemical Name

Methanesulfonamide, N-(1'-(2-(2,1,3-benzoxadiazol-5-yl)ethyl)-3,4-dihydro-4-oxospiro(2H-1-benzopyran-2,4'-piperidin)-6-yl)-

InChi Key

UISIMLLBTGLBND-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H24N4O5S/c1-32(28,29)25-16-3-5-21-17(13-16)20(27)14-22(30-21)7-10-26(11-8-22)9-6-15-2-4-18-19(12-15)24-31-23-18/h2-5,12-13,25H,6-11,14H2,1H3

SMILES Code

CS(=O)(NC1=CC=C2C(C(CC3(CCN(CCC4=CC5=NON=C5C=C4)CC3)O2)=O)=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 456.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lynch JJ Jr, Wallace AA, Van der Gaag LH, Baskin EP, Bear CM, Gehret JR, Kothstein T, Stupienski RF, Appleby SD, Sanguinetti MC, et al. Cardiac electrophysiologic and antiarrhythmic actions of 3,4-dihydro-1'-[2-(benzofurazan-5-yl) ethyl]-6-methanesulfonamidospiro [(2H)-1-benzopyran-2,4'-piperidin]-4-one HCl (L-691,121), a novel class III agent. J Pharmacol Exp Ther. 1993 May;265(2):720-30. PMID: 8496818. 2: Elliott JM, Selnick HG, Claremon DA, Baldwin JJ, Buhrow SA, Butcher JW, Habecker CN, King SW, Lynch JJ Jr, Phillips BT, et al. 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). J Med Chem. 1992 Oct 16;35(21):3973-6. doi: 10.1021/jm00099a028. PMID: 1433205. 3: Greber TF, Olah TV, Gilbert JD, Porras AG, Hichens M. Determination of L-691,121, a new class III antiarrhythmic, and its principal metabolite in plasma by differential radioimmunoassay. J Pharm Biomed Anal. 1994 Apr;12(4):483-92. doi: 10.1016/0731-7085(94)80029-4. PMID: 7918764. 4: Zaniboni M, Pollard AE, Yang L, Spitzer KW. Beat-to-beat repolarization variability in ventricular myocytes and its suppression by electrical coupling. Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H677-87. doi: 10.1152/ajpheart.2000.278.3.H677. PMID: 10710334. 5: Ban Y, Konishi R, Kawana K, Nakatsuka T, Fujii T, Manson JM. Embryotoxic effects of L-691,121, a class III antiarrhythmic agent, in rats. Arch Toxicol. 1994;69(1):65-71. doi: 10.1007/s002040050139. PMID: 7717857. 6: Vickers S, Duncan CA, Kari PH, Homnick CF, Elliott JM, Pitzenberger SM, Hichens M, Vyas KP. In vivo and in vitro metabolism studies on a class III antiarrhythmic agent. Drug Metab Dispos. 1993 May-Jun;21(3):467-73. PMID: 8100503.