MedKoo Cat#: 462313 | Name: TMN 355
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TMN-355 is a novel small-molecule modulator that targets nuclear receptor signaling pathways, influencing gene transcription and cellular metabolism. Its core structure consists of a substituted heterocyclic scaffold designed for high receptor binding affinity, optimizing selectivity while minimizing off-target effects. Preliminary in vitro studies suggest its potential in metabolic disorder research, with promising pharmacokinetic properties for further preclinical evaluation.

Chemical Structure

TMN 355
TMN 355
CAS#1186372-20-2

Theoretical Analysis

MedKoo Cat#: 462313

Name: TMN 355

CAS#: 1186372-20-2

Chemical Formula: C21H14ClFN2O2

Exact Mass: 380.0728

Molecular Weight: 380.80

Elemental Analysis: C, 66.24; H, 3.71; Cl, 9.31; F, 4.99; N, 7.36; O, 8.40

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
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Synonym
TMN 355; TMN355; TMN-355
IUPAC/Chemical Name
2-chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluoro-benzamide
InChi Key
SFNLLCUAISZNRV-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H14ClFN2O2/c22-16-10-5-11-17(23)18(16)20(26)25-21(27)24-19-14-8-3-1-6-12(14)13-7-2-4-9-15(13)19/h1-11,19H,(H2,24,25,26,27)
SMILES Code
O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 380.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ni, S., Yuan, Y., Huang, J., et al. Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J. Med. Chem. 52(17), 5295-5298 (2009). 2: Gale, T.V., Horton, T.M., Hoffmann, A.R., et al. Host proteins identified in extracellular viral particles as targets for broad-spectrum antiviral inhibitors. J. Proteome Res. 18(1), 7-17 (2019).