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MedKoo Cat#: 535006 | Name: Epidepride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epidepride is a bioactive chemical.

Chemical Structure

Epidepride
Epidepride
CAS#107188-87-4

Theoretical Analysis

MedKoo Cat#: 535006

Name: Epidepride

CAS#: 107188-87-4

Chemical Formula: C16H23IN2O3

Exact Mass: 418.0753

Molecular Weight: 418.28

Elemental Analysis: C, 45.94; H, 5.54; I, 30.34; N, 6.70; O, 11.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Epidepride
IUPAC/Chemical Name
Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-iodo-2,3-dimethoxy-, (S)-
InChi Key
APNNSBJHVTUORL-LBPRGKRZSA-N
InChi Code
InChI=1S/C16H23IN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1
SMILES Code
O=C(NC[C@H]1N(CC)CCC1)C2=CC(I)=CC(OC)=C2OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 418.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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[123I]Epidepride neuroimaging of dopamine D2/D3 receptor in chronic MK-801-induced rat schizophrenia model. Nucl Med Biol. 2012 Aug;39(6):826-32. doi: 10.1016/j.nucmedbio.2012.01.005. Epub 2012 Mar 29. PMID: 22464847. 5: Almeida P, Ribeiro MJ, Bottlaender M, Loc'h C, Langer O, Strul D, Hugonnard P, Grangeat P, Mazière B, Bendriem B. Absolute quantitation of iodine-123 epidepride kinetics using single-photon emission tomography: comparison with carbon-11 epidepride and positron emission tomography. Eur J Nucl Med. 1999 Dec;26(12):1580-8. doi: 10.1007/s002590050498. PMID: 10638410. 6: de Herder WW, Reijs AE, de Swart J, Kaandorp Y, Lamberts SW, Krenning EP, Kwekkeboom DJ. Comparison of iodine-123 epidepride and iodine-123 IBZM for dopamine D2 receptor imaging in clinically non-functioning pituitary macroadenomas and macroprolactinomas. Eur J Nucl Med. 1999 Jan;26(1):46-50. doi: 10.1007/s002590050358. PMID: 9933661. 7: Neve KA, Henningsen RA, Kinzie JM, De Paulis T, Schmidt DE, Kessler RM, Janowsky A. Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand. J Pharmacol Exp Ther. 1990 Mar;252(3):1108-16. PMID: 2138666. 8: Tibbo P, Silverstone PH, McEwan AJ, Scott J, Joshua A, Golberg K. A single photon emission computed tomography scan study of striatal dopamine D2 receptor binding with 123I-epidepride in patients with schizophrenia and controls. J Psychiatry Neurosci. 1997 Jan;22(1):39-45. PMID: 9002391; PMCID: PMC1188815. 9: Pirker W, Riedl M, Luger A, Czech T, Rössler K, Asenbaum S, Angelberger P, Kornhuber J, Deecke L, Podreka I, Brücke T. Dopamine D2 receptor imaging in pituitary adenomas using iodine-123-epidepride and SPECT. J Nucl Med. 1996 Dec;37(12):1931-7. PMID: 8970508. 10: Hall H, Farde L, Halldin C, Hurd YL, Pauli S, Sedvall G. Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride. Synapse. 1996 Jun;23(2):115-23. doi: 10.1002/(SICI)1098-2396(199606)23:2<115::AID-SYN7>3.0.CO;2-C. PMID: 8723716. 11: Langer O, Halldin C, Dollé F, Swahn CG, Olsson H, Karlsson P, Hall H, Sandell J, Lundkvist C, Vaufrey F, Loc'h C, Crouzel C, Mazière B, Farde L. Carbon-11 epidepride: a suitable radioligand for PET investigation of striatal and extrastriatal dopamine D2 receptors. Nucl Med Biol. 1999 Jul;26(5):509-18. doi: 10.1016/s0969-8051(99)00005-0. PMID: 10473189. 12: Kessler RM, Ansari MS, Schmidt DE, de Paulis T, Clanton JA, Innis R, al- Tikriti M, Manning RG, Gillespie D. High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors. Life Sci. 1991;49(8):617-28. doi: 10.1016/0024-3205(91)90261-9. PMID: 1830917. 13: Pinborg LH, Videbaek C, Ziebell M, Mackeprang T, Friberg L, Rasmussen H, Knudsen GM, Glenthoj BY. [123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region. Neuroimage. 2007 Feb 15;34(4):1450-3. doi: 10.1016/j.neuroimage.2006.11.003. Epub 2006 Dec 18. PMID: 17175177. 14: Leung K. (S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[18F] fluoropropyl)-2-methoxybenzamide. 2006 Aug 3 [updated 2008 May 17]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641474. 15: Pirker W, Asenbaum S, Wenger S, Kornhuber J, Angelberger P, Deecke L, Podreka I, Brücke T. Iodine-123-epidepride-SPECT: studies in Parkinson's disease, multiple system atrophy and Huntington's disease. J Nucl Med. 1997 Nov;38(11):1711-7. PMID: 9374338. 16: Leung K. (+/-)-2-(N-Cyclohexylethyl-N-[11C]propyl)a mino-5-hydroxytetralin. 2006 Aug 16 [updated 2008 Feb 4]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641389. 17: Leung K. (R,S)-2-(N-Propyl-N-5'-[18F] fluoropentyl)amino-5-hydroxytetralin. 2006 Aug 27 [updated 2008 Feb 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641295. 18: Baldwin RM, Zea-Ponce Y, Zoghbi SS, al-Tikriti MS, Seibyl JP, Sybirska EH, Malison RT, Laruelle M, Charney DS, Hoffer PB, et al. Pharmacokinetics of the three radioiodinated dopamine D2 receptor ligands [123I]IBF, [123I]epidepride and [123I]2'-ISP in nonhuman primates. Nucl Med Biol. 1994 Oct;21(7):969-76. doi: 10.1016/0969-8051(94)90087-6. PMID: 9234352. 19: Leung K. (R)-2-[11C]Methoxy-N-n-propylnorapomorphine. 2006 Apr 11 [updated 2012 Feb 1]. 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