Reversan is an inhibitor of multidrug resistance-associated proteins (MRPs), particularly MRP1. It enhances the efficacy of chemotherapeutic agents by blocking the efflux activity of MRP1, which is often overexpressed in cancer cells and contributes to drug resistance. Reversan has demonstrated chemosensitizing effects in preclinical models, notably improving the cytotoxicity of agents like etoposide and doxorubicin in neuroblastoma and other cancer cell lines. Unlike broad-spectrum efflux pump inhibitors, Reversan exhibits lower toxicity and greater selectivity, making it a promising candidate for overcoming drug resistance in cancer therapy.
MedKoo Cat#: 462304
Name: Reversan
CAS#: 313397-13-6
Chemical Formula: C26H27N5O2
Exact Mass: 441.2165
Molecular Weight: 441.54
Elemental Analysis: C, 70.73; H, 6.16; N, 15.86; O, 7.25
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.0 | 25.00 |
The following data is based on the product molecular weight 441.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
