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MedKoo Cat#: 534977 | Name: Otilonium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Otilonium is a bioactive chemical.

Chemical Structure

Otilonium
Otilonium
CAS#105360-89-2

Theoretical Analysis

MedKoo Cat#: 534977

Name: Otilonium

CAS#: 105360-89-2

Chemical Formula: C29H43N2O4+

Exact Mass: 483.3217

Molecular Weight: 483.67

Elemental Analysis: C, 72.02; H, 8.96; N, 5.79; O, 13.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Otilonium
IUPAC/Chemical Name
Ethanaminium, N,N-diethyl-N-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-
InChi Key
NQHNLNLJPDMBFN-UHFFFAOYSA-O
InChi Code
InChI=1S/C29H42N2O4/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3/h12-13,15-20H,5-11,14,21-23H2,1-4H3/p+1
SMILES Code
O=C(OCC[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 483.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Evangelista S, Traini C, Vannucchi MG. Otilonium Bromide: A Drug with a Complex Mechanism of Action. Curr Pharm Des. 2018;24(16):1772-1779. doi: 10.2174/1381612824666180507122935. PMID: 29732965. 2: García-Alvarado F, Govoni G, de Pascual R, Ruiz-Ruiz C, Muñoz-Montero A, Gandía L, de Diego AMG, García AG. Otilonium and pinaverium trigger mitochondrial-mediated apoptosis in rat embryo cortical neurons in vitro. Neurotoxicology. 2019 Jan;70:99-111. doi: 10.1016/j.neuro.2018.11.003. Epub 2018 Nov 15. PMID: 30448301. 3: Clavé P, Tack J. Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis. Therap Adv Gastroenterol. 2017 Mar;10(3):311-322. doi: 10.1177/1756283X16681708. Epub 2017 Jan 16. PMID: 28246548; PMCID: PMC5305018. 4: Kim JI, Kim P, Lee JH, Kim YJ, Yang NR, Baeg MK, Choi JS, Kim HJ, Kim J, Sunwoo YY, Lee JH, Ha H, Park TY. Effect of herbal extract granules combined with otilonium bromide on irritable bowel syndrome with diarrhoea: a study protocol for a randomised controlled trial. BMJ Open. 2017 Dec 1;7(11):e018362. doi: 10.1136/bmjopen-2017-018362. PMID: 29196484; PMCID: PMC5719308. 5: Lee JH, Kim JI, Baeg MK, Sunwoo YY, Do K, Lee JH, Kim HJ, Choi JS, Kim J, Seo CS, Shin HK, Ha H, Park TY. Effect of Samryungbaekchul-san Combined with Otilonium Bromide on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial. J Clin Med. 2019 Sep 27;8(10):1558. doi: 10.3390/jcm8101558. PMID: 31569833; PMCID: PMC6832362. 6: Boeckxstaens G, Corazziari ES, Mearin F, Tack J. IBS and the role of otilonium bromide. Int J Colorectal Dis. 2013 Mar;28(3):295-304. doi: 10.1007/s00384-012-1598-0. Epub 2012 Nov 22. PMID: 23178991. 7: Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014 May 28;20(20):6031-43. doi: 10.3748/wjg.v20.i20.6031. PMID: 24876726; PMCID: PMC4033443. 8: Somuncu E, Sarici İS, Caliskan YK, Kalayci MU. Preprocedural Administration of Simethicone and Otilonium Bromide Improves the Quality of Endoscopic Retrograde Cholangiopancreatography: A Prospective Randomized Trial. Surg Laparosc Endosc Percutan Tech. 2019 Aug;29(4):252-254. doi: 10.1097/SLE.0000000000000646. PMID: 30768493. 9: Forte E, Pizzoferrato M, Lopetuso L, Scaldaferri F. The use of anti- spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide. Eur Rev Med Pharmacol Sci. 2012 Jan;16(1):25-37. PMID: 22338545. 10: Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez- Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ. Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis. Rev Gastroenterol Mex. 2012 Apr- Jun;77(2):82-90. doi: 10.1016/j.rgmx.2012.04.002. Epub 2012 Jun 5. PMID: 22672854. 11: Battaglia G, Morselli-Labate AM, Camarri E, Francavilla A, De Marco F, Mastropaolo G, Naccarato R. Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10. doi: 10.1046/j.1365-2036.1998.00397.x. PMID: 9798806. 12: Gandía L, Villarroya M, Lara B, Olmos V, Gilabert JA, López MG, Martínez- Sierra R, Borges R, García AG. Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol. 1996 Feb;117(3):463-470. doi: 10.1111/j.1476-5381.1996.tb15213.x. PMID: 8821535; PMCID: PMC1909307. 13: Boeckxstaens G, Clavé P, Corazziari ES, Tack J. Irritable bowel syndrome: focus on otilonium bromide. Expert Rev Gastroenterol Hepatol. 2014 Feb;8(2):131-7. doi: 10.1586/17474124.2014.869477. PMID: 24417261. 14: Traini C, Evangelista S, Girod V, Faussone-Pellegrini MS, Vannucchi MG. Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress. J Cell Mol Med. 2017 Apr;21(4):735-745. doi: 10.1111/jcmm.13016. Epub 2016 Nov 20. PMID: 27866394; PMCID: PMC5345670. 15: Martin MT, Hove-Madsen L, Jimenez M. Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon. Neurogastroenterol Motil. 2004 Apr;16(2):175-83. doi: 10.1111/j.1365-2982.2004.00518.x. PMID: 15086871. 16: Karahan Ö, Sevinç B, Okuş A, Ay S, Aksoy N. Otilonium bromide as spasmolytic during endoscopic retrograde cholangiopancreatography. Surg Endosc. 2015 Aug;29(8):2266-9. doi: 10.1007/s00464-014-3939-2. Epub 2014 Nov 1. PMID: 25361657. 17: Triantafillidis JK, Malgarinos G. Long-term efficacy and safety of otilonium bromide in the management of irritable bowel syndrome: a literature review. Clin Exp Gastroenterol. 2014 Apr 7;7:75-82. doi: 10.2147/CEG.S46291. PMID: 24741324; PMCID: PMC3984067. 18: Kim JW. Is otilonium bromide really effective for treating asian patients with irritable bowel syndrome? J Neurogastroenterol Motil. 2012 Jan;18(1):109-10. doi: 10.5056/jnm.2012.18.1.109. Epub 2012 Jan 16. PMID: 22323998; PMCID: PMC3271245. 19: Chang FY. Is Otilonium Bromide Really Effective for Treating Asian Patients With Irritable Bowel Syndrome?: Author's Reply. J Neurogastroenterol Motil. 2012 Jan;18(1):111-2. doi: 10.5056/jnm.2012.18.1.111. Epub 2012 Jan 16. PMID: 22323999; PMCID: PMC3271246. 20: Desborough MJ, Ford AC. Is otilonium bromide globally effective in irritable bowel syndrome? Aliment Pharmacol Ther. 2011 Oct;34(8):1034-5; author reply 1035-6. doi: 10.1111/j.1365-2036.2011.04769.x. PMID: 21933208.

View History

JNJ-64326067

JNJ-64326067