Proterguride | CAS#77650-95-4

MedKoo Cat#: 534976 | Name: Proterguride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Proterguride is a bioactive chemical.

Chemical Structure

Proterguride

CAS#77650-95-4

Theoretical Analysis

MedKoo Cat#: 534976

Name: Proterguride

CAS#: 77650-95-4

Chemical Formula: C22H32N4O

Exact Mass: 368.2576

Molecular Weight: 368.53

Elemental Analysis: C, 71.70; H, 8.75; N, 15.20; O, 4.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Proterguride

IUPAC/Chemical Name

Urea, N,N-diethyl-N'-((8-alpha)-6-propylergolin-8-yl)-

InChi Key

FCRJELOYDVBTGW-ILZDJORESA-N

InChi Code

InChI=1S/C22H32N4O/c1-4-10-26-14-16(24-22(27)25(5-2)6-3)12-18-17-8-7-9-19-21(17)15(13-23-19)11-20(18)26/h7-9,13,16,18,20,23H,4-6,10-12,14H2,1-3H3,(H,24,27)/t16-,18+,20+/m0/s1

SMILES Code

O=C(N[C@@H](C[C@@]12[H])CN(CCC)[C@]1([H])CC3=CNC4=C3C2=CC=C4)N(CC)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 368.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schurad B, Horowski R, Jähnichen S, Görnemann T, Tack J, Pertz HH. Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors. Life Sci. 2006 Apr 11;78(20):2358-64. doi: 10.1016/j.lfs.2005.09.046. Epub 2005 Nov 28. PMID: 16310806. 2: Schurad B, Tack J, Lipp R. Evaluation of the transdermal permeation behavior of Proterguride from drug in adhesive matrix patches through hairless mouse skin. Drug Dev Ind Pharm. 2005 Jul;31(6):505-13. doi: 10.1080/03639040500215842. PMID: 16109623. 3: Krause W, Düsterberg B, Jakobs U, Hoyer GA. Biotransformation of proterguride in the perfused rat liver. Drug Metab Dispos. 1993 Mar-Apr;21(2):203-8. PMID: 8097686. 4: Brücke T, Bankiewicz K, Harvey-White J, Kopin I. The partial dopamine receptor agonist terguride in the MPTP-induced hemiparkinsonian monkey model. Eur J Pharmacol. 1988 Apr 13;148(3):445-8. doi: 10.1016/0014-2999(88)90125-2. PMID: 3260191. 5: Krause W, Hümpel M. Pharmacokinetics of proterguride in rat and cynomolgus monkey. Xenobiotica. 1988 Jan;18(1):41-8. doi: 10.3109/00498258809055135. PMID: 3354231.