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MedKoo Cat#: 462281 | Name: SB-200646 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB-200646 HCl is a dual antagonist of the serotonin (5-HT) receptor subtypes 5-HT2C and 5-HT2B.

Chemical Structure

SB-200646 HCl
SB-200646 HCl
CAS#143797-62-0

Theoretical Analysis

MedKoo Cat#: 462281

Name: SB-200646 HCl

CAS#: 143797-62-0

Chemical Formula: C15H15ClN4O

Exact Mass: 0.0000

Molecular Weight: 302.76

Elemental Analysis: C, 59.51; H, 4.99; Cl, 11.71; N, 18.51; O, 5.28

Price and Availability

Size Price Availability Quantity
1mg USD 205.00 2 Weeks
5mg USD 384.00 2 Weeks
10mg USD 625.00 2 Weeks
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Related CAS #
No Data
Synonym
SB-200646 hydrochloride; SB200646 hydrochloride; SB 200646 hydrochloride; SB-200646 HCl; SB200646 HCl; SB 200646 HCl
IUPAC/Chemical Name
N-(1-methyl-1H-indol-5-yl)-N′-3-pyridinyl-urea, monohydrochloride
InChi Key
IGRYPUQJEDJLHC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14N4O.ClH/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13;/h2-10H,1H3,(H2,17,18,20);1H
SMILES Code
O=C(NC1=CC(C=CN2C)=C2C=C1)NC3=CC=CN=C3.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SB-200646 is a dual antagonist of 5-HT receptor subtypes 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B (pA2 = 7.5 in rat stomach fundus preparations). It is selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all).
In vitro activity:
To be determined
In vivo activity:
Acute and chronic administration of SB-200646 HCl resulted in various changes in the firing rate, bursting activity, and number of spontaneously active dopamine neurons in the substantia nigra pars compacts and ventral tegmental area of anesthetized rats. Specifically, the administration of SB-200646 HCl led to alterations in firing patterns and neuronal activity resembling those associated with atypical antipsychotic drugs. Reference: Synapse. 2006 Jun 15;59(8):502-12. https://pubmed.ncbi.nlm.nih.gov/16565966/
Solvent mg/mL mM
Solubility
DMSO 250.0 825.74
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 302.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Blackburn TP, Suzuki K, Ashby CR Jr. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12. doi: 10.1002/syn.20263. PMID: 16565966. 2. Meneses A. Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism? Cell Mol Neurobiol. 2002 Dec;22(5-6):675-88. doi: 10.1023/a:1021800822997. PMID: 12585687.
In vitro protocol:
To be determined
In vivo protocol:
1. Blackburn TP, Suzuki K, Ashby CR Jr. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12. doi: 10.1002/syn.20263. PMID: 16565966. 2. Meneses A. Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism? Cell Mol Neurobiol. 2002 Dec;22(5-6):675-88. doi: 10.1023/a:1021800822997. PMID: 12585687.
1: Kennett, G.A., Wood, M.D., Glen, A., et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br. J. Pharmacol. 111(3), 797-802 (1994).