IUPAC/Chemical Name
1H-Pyrido(4,3,2-mn)thiazolo(5,4-b)acridine-9-ethanamine, N,N,1-trimethyl-
InChi Key
COKHRCLLFPZOEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20N4S/c1-24(2)10-8-15-18-17-14(13-6-4-5-7-16(13)23-18)9-11-25(3)20(17)21-19(15)22-12-26-21/h4-7,9,11-12H,8,10H2,1-3H3
SMILES Code
CN1C=CC2=C(C1=C(SC=N3)C3=C4CCN(C)C)C4=NC5=CC=CC=C52
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
360.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mazzaferro V, El-Rayes BF, Droz Dit Busset M, Cotsoglou C, Harris WP, Damjanov N, Masi G, Rimassa L, Personeni N, Braiteh F, Zagonel V, Papadopoulos KP, Hall T, Wang Y, Schwartz B, Kazakin J, Bhoori S, de Braud F, Shaib WL. Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma. Br J Cancer. 2019 Jan;120(2):165-171. doi: 10.1038/s41416-018-0334-0. Epub 2018 Nov 13. PMID: 30420614; PMCID: PMC6342954.
2: Burres NS, Sazesh S, Gunawardana GP, Clement JJ. Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge. Cancer Res. 1989 Oct 1;49(19):5267-74. PMID: 2548717.
3: Longley RE, McConnell OJ, Essich E, Harmody D. Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity. J Nat Prod. 1993 Jun;56(6):915-20. doi: 10.1021/np50096a015. PMID: 8350092.
4: Taraporewala IB, Cessac JW, Chanh TC, Delgado AV, Schinazi RF. HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids. J Med Chem. 1992 Jul 24;35(15):2744-52. doi: 10.1021/jm00093a005. PMID: 1495008.
