MedKoo Cat#: 574475 | Name: Holomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity.

Chemical Structure

Holomycin
Holomycin
CAS#488-04-0

Theoretical Analysis

MedKoo Cat#: 574475

Name: Holomycin

CAS#: 488-04-0

Chemical Formula: C7H6N2O2S2

Exact Mass: 213.9871

Molecular Weight: 214.26

Elemental Analysis: C, 39.24; H, 2.82; N, 13.07; O, 14.93; S, 29.93

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Synonym
Holomycin
IUPAC/Chemical Name
N-(5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
InChi Key
HBUNPJGMNVQSBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H6N2O2S2/c1-3(10)8-5-6-4(2-12-13-6)9-7(5)11/h2H,1H3,(H,8,10)(H,9,11)
SMILES Code
CC(=O)NC1=C2C(=CSS2)NC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity.
In vitro activity:
Collectively, these data suggest that holomycin promotes biofilm formation of S2753 via its ene-disulfide group. Reference: Appl Environ Microbiol. 2021 May 11;87(11):e00169-21. https://pubmed.ncbi.nlm.nih.gov/33771780/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 214.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhang SD, Isbrandt T, Lindqvist LL, Larsen TO, Gram L. Holomycin, an Antibiotic Secondary Metabolite, Is Required for Biofilm Formation by the Native Producer Photobacterium galatheae S2753. Appl Environ Microbiol. 2021 May 11;87(11):e00169-21. doi: 10.1128/AEM.00169-21. PMID: 33771780; PMCID: PMC8208159.
In vitro protocol:
1. Zhang SD, Isbrandt T, Lindqvist LL, Larsen TO, Gram L. Holomycin, an Antibiotic Secondary Metabolite, Is Required for Biofilm Formation by the Native Producer Photobacterium galatheae S2753. Appl Environ Microbiol. 2021 May 11;87(11):e00169-21. doi: 10.1128/AEM.00169-21. PMID: 33771780; PMCID: PMC8208159.
In vivo protocol:
TBD