AT-112, also known as 2-PMDQ, is an α1-adrenoceptor antagonist and antihypertensive. Its antihypertensive action is mainly mediated by the blockade of the alpha 1-adrenoceptor. In in vitro study, the vasodilating effect of AT-112 on isolated thoracic aorta was endothelium-independent. AT-112 was found to be a potent alpha 1-adrenoceptor blocking agent in the rat thoracic aorta as revealed by its competitive antagonism of phenylephrine (pA2 = 9.82 +/- 0.19), but was found to have noncompetitive antagonism to 5-HT. The IC50 of ketanserin and AT-112 to phenylephrine were 27.8 nM and 0.36 nM, respectively, and to 5-HT were 5.73 nM and 0.44 microM, respectively.
MedKoo Cat#: 462215
Name: AT-112
CAS#: 139047-55-5
Chemical Formula: C21H23N5O
Exact Mass: 361.1903
Molecular Weight: 361.45
Elemental Analysis: C, 69.78; H, 6.41; N, 19.38; O, 4.43
The following data is based on the product molecular weight 361.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
